但作为点击化学中最为经典的CuAAC(Copper(I)-catalyzed Azide-Alkyne Cycloaddition, 铜催化叠氮-炔环加成)反应,其从反应形式上可看作是Cu(I)催化的Huisgen反应。 然而,尽管CuAAC反应的发现者Sharpless教授在论文题目中使用了“A Stepwise Huisgen Cycloaddition Process” 的表述,但因该反应与经典的Huisgen反应在机理...
Cu Catalyzed Alkyne Azide Cycloaddition “点击化学”是由K. B. Sharpless在2001年提出的一个术语,用来描述高产、范围广、只产生无需色谱法即可去除的副产品、立体特异性、操作简单、可在容易去除或无害的溶剂中进行的反应[1]。第一个符合“点击化学”概念的反应即铜催化的叠氮–炔烃环加成反应。该反应是在Huisgen...
The copper catalysis in the Huisgen reaction broadly known as the azide/ alkyne reaction or CuAAC reaction has been discussed. This simple and robust reaction, which involves clusters of Cu and ligands, has led to exclusive formation of the 1,4-isomer. It is vital to maintain a good ...
cycloaddition reactionsChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is ...
Ligand-Accelerated Cu-Catalyzed Azide-Alkyne Cycloaddition: A Mechanistic Report The experimental rate law for the Cu(l)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction was found to vary in complex ways with concentration, the pre... VO Rodionov,SI Presolski,David Dfaz Dfaz,... - 《Jo...
点击化学的代表反应为铜催化的叠氮-炔基环加成反应(Copper-Catalyzed Azide–Alkyne Cycloaddition,CuAAC),该反应具有步骤简单、底物不敏感和高效的特点,并可以用于聚合物系统中。 针对这一领域,来自马丁路德·哈勒维腾贝格大学的Wolfgang H. Binder及合作者回顾了CuAAC的基本原理,包括均相/非均相催化剂、配体和邻位...
[1] Presolski et al. (2011) Copper-Catalyzed Azide-Alkyne Click Chemistry for Bioconjugation. Current Protocols in Chemical Biology 3:153. [2] Hong et al. (2011) Analysis and Optimization of Copper-Catalyzed Azide-Alkyne Cycloaddition for Bioconjugation. Angew. Chem. Int. Ed. 48:9879. ...
[1] Presolski et al. (2011) Copper-Catalyzed Azide-Alkyne Click Chemistry for Bioconjugation. Current Protocols in Chemical Biology 3:153. [2] Hong et al. (2011) Analysis and Optimization of Copper-Catalyzed Azide-Alkyne Cycloaddition for Bioconjugation. Angew. Chem. Int. Ed. 48:9879. ...
[1] Presolski et al. (2011) Copper-Catalyzed Azide-Alkyne Click Chemistry for Bioconjugation. Current Protocols in Chemical Biology 3:153. [2] Hong et al. (2011) Analysis and Optimization of Copper-Catalyzed Azide-Alkyne Cycloaddition for Bioconjugation. Angew. Chem. Int. Ed. 48:9879. ...
[1] Presolski et al. (2011) Copper-Catalyzed Azide-Alkyne Click Chemistry for Bioconjugation. Current Protocols in Chemical Biology 3:153. [2] Hong et al. (2011) Analysis and Optimization of Copper-Catalyzed Azide-Alkyne Cycloaddition for Bioconjugation. Angew. Chem. Int. Ed. 48:9879. ...