(FICI ≤ 0.5);甘草酸可竞争性抑制 β- 内酰胺酶对底物抗生素的水解作用,对头孢噻肟钠的抑酶保护率可达 58.53%,与克拉维酸接近(60.98%).【结论】中药单体甘草 酸可与 CTX-M-14 蛋白稳定结合,通过竞争性抑制 β- 内酰胺酶对底物抗生素的水解作用,提高多重耐药大肠杆菌 E320 和重组蛋白 阳性菌 BL-21 对...
CTX—M-14型超广谱β-酰胺酶原核表达载体的构建及其抗药活性分析
目的了解多药耐药大肠埃希菌携带质粒介导的CTX-M-14与CTX-M-15酶基因分布及其对常见抗菌药物的耐药性,为临床合理选择抗菌药物提供依据。方法收集2007年7月-2008年7月感染患者送检标本中分离出的大肠埃希菌71株,采用纸片扩散法(K-B法)对其中多耐30株、双耐19株及单耐16株大肠埃希菌进行药物敏感试验,提取质粒DNA,...
目的了解头孢他啶等几种抗生素治疗产头孢噻肟-水解酶14型(CTX-M-14型)超广谱 β-内酰胺酶(ESBLs)大肠埃希菌所致的细菌性腹膜炎的治疗效果.方法在家兔腹腔内注射产CTX—M-14型ESBLs接合菌 3×10^8cfu/ml,制备家兔细菌性腹膜炎模型.应用随机数字表法将133只制备成细菌性腹膜炎模型的家兔分为4组,1组为对照...
time-resolved serial crystallography was employed to obtain mechanistic insights into binding to the active site serine of β-lactamase CTX-M-14, identifying a reaction time frame of 80–100 ms. In a next step, the subsequent 1,2-diol boric ester formation with glycerol in the active site...
弗劳地枸橼酸杆菌中质粒介导的 KPC-2 型碳青霉烯酶和 CTX-M-14 型超广谱β-内酰胺酶的检出 蔡加昌 张 嵘 周宏伟 陈功祥 浙江大学医学院附属浙医二院检验科 枸橼酸杆菌为条件致病菌 当机体抵抗力下降时可引起腹泻和肠道外感染如败血症、脑膜炎、泌尿道、呼吸道及创伤感染等。根据中国医院内病原菌耐药监测网 ...
上海发现同时产CYM-2型质粒AmpC酶及CTX-M-14型超广谱β-内酰胺酶的大肠埃希菌 维普资讯 http://www.cqvip.com
This is the first report of CTX-M-14 in S. sonnei isolates from China and it is important to closely monitor such strains. 展开 关键词: Shigella sonneiResistance Antimicrobial agents Extended-spectrum β-lactamases DOI: 10.1016/j.jinf.2007.07.017 被引量: 76 ...
Using boric acid as a simplified inhibitor model, time-resolved serial crystallography was employed to obtain mechanistic insights into binding to the active site serine of β-lactamase CTX-M-14, identifying a reaction time frame of 80–100 ms. In a next step, the subsequent 1,2-diol ...
Among 603 isolates of Enterobacteriaceae collected between June and November 2003 from three university hospitals within Korea, bla(CTX-M-3), bla(CTX-M-15), bla(CTX-M-14), and bla(CTX-M-9) were detected in 41 isolates of species from five different genera of Enterobacteriaceae, Escherichia...