The present invention relates to a CTLA4-Ig fusion protein, in which an extracellular region of the CTLA4 is connected to CH2, CH3, and CH4 of IgM or to hinge, CH2 and CH3 of IgG1 Cys308, and six monomers of which are polymerized to be a hexameric structure. According to the present...
Expression and biological activities of CTLA4-Ig fusion protein ZHENG Yu, SHEN Beifeng, LI Yan, SHU Cuiling, HU Meiru, PEI Wuhong, WANG Jianan Institute of Basic Medical Sciences, Acadamy of Military Medical Sciences, Beijing 100850, China Abstract: Aim To obtain and express the CTLA4 gene in...
A fusion protein, CTLA4-Ig, consisting of the extracellular domain of CTLA4 in combination with the constant region of the human immunoglobulin Cy chain, has been developed to investigate the effects of inhibition of the B7/CD28 costimulatory pathway on transplant rejection. CTLA4-Ig acts as a co...
A mixture of stimulated human PBL's and human CTLA4 Ig fusion protein。 来源宿主 小鼠 反应性 人 保存建议 置于4度温度保存。 其他 作为全世界最大的单克隆抗体和蛋白生产商,Abnova的金牌品质使其成为全球最主要抗体品牌的供应商,您可以在各个主要抗体品牌,如Abcam、 Sigma、Novus、AbD等知名品牌的目录上都能...
THU0542 In Vitro Anti-Inflammatory Effects of Dexamethasone and Ctla4-Ig (ABATACEPT) Combined TreatmentBackground In rheumatoid arthritis (RA) the combination of glucocorticoids (GC) and the fusion protein CTLA4-Ig (abatacept) allows to obtain better clinical improvement than CTLA4-Ig monotherapy. ...
While the key function of endogenous Treg CTLA4 in trans-endocytosis of costimulation [31] is not replicated by CTLA4-Ig, the fusion protein competitively binds CD80/CD86, repressing CD28 costimulation in T cells [3, 15, 16]. In addition to its widespread usage in common autoimmune conditions,...
CTLA4一Ig能诱导经脾同 种异体肝细胞移植大鼠免疫耐受,使急性肝衰大鼠肝功能得到改善。可能是抑制T淋巴细胞亚群,且 主要是抑制CIMT细胞,使CIM/CD8T细胞比值下降;抑制IL一2的分泌。 【关键词】肝细胞移植;免疫耐受 RatallogeneichepatocytetransplantationimmunetoleranceinducedbyCTLA4-Ig ...
Embodiments of the invention include CTLA4Ig fusion protein, and hybrid fusion proteins including CD28/CTLA4Ig fusion proteins (which is also referred to herein as the CTLA4/CD28Ig fusion protein). Also provided are methods for using the CTLA4 fusion protein, B7Ig fusion protein, hybrid fusion ...
The present application relates to CTLA4-Ig immunoadhesins that target CD80 and CD86, and their use, particularly for therapeutic purposes.
Thus, expression (i.e., transcription and translation) of the nucleotide sequences produces a functional CTLA4Ig fusion protein. In the case of the CTLA4-Ab fusion proteins, the heavy chain gene is constructed such that the CTLA4 extracellular binding domain is linked to a 5′ signal sequence...