DESCRIPTION Species Reactivity Human SpecificityDetects human CTLA4 in direct ELISAs and Western blots. Shows approximately 10% crossreactivity with recombinant mouse CTLA4 andno crossreactivity with recombinant human (rh) CD28 or...
Antibody 克隆号 060 抗原 Recombinant Human CTLA-4/CD152 protein (Met1-Phe162) 查看免疫原 偶联物 Unconjugated 形式 Liquid 浓度 1 mg/mL 纯化类型 Protein A 保存液 PBS 内含物 no preservative 保存条件 Store at 4°C short term. For long term storage, store at ...
抗体名: CTLA-4|CTLA-4antibody|CTLA-4抗体(anti-Mouse兔单抗) 浓度: ELISA: 1:5000-1:10000 % 靶点: CTLA4 宿主: Rabbit 应用范围: ELISA 产地: 北京 品牌: Sino Biological/义翘神州 货号: 50503-R037 亚型: Rabbit IgG 是否单克隆: 是 免疫原: Recombinant Mouse CTLA-4 / CD152 prote...
Antibody 克隆号 11HCLC 抗原 Protein corresponding to Human CTLA4 (aa 186-223) 查看免疫原 偶联物 Unconjugated 形式 Liquid 浓度 0.5 mg/mL 纯化类型 Protein A 保存液 PBS, pH 7.4 内含物 0.09% sodium azide 保存条件 Store at 4°C short term. For long term stor...
anti-CTLA-4 抗体通过抗体依赖的细胞毒作用(antibody-dependent cellular cytotoxicity,ADCC)清除肿瘤微环境中的调节性 T 细胞(Tregs),以实现癌症免疫治疗效果(CITE)。研究人员使用具有高灵敏度发光检测功能的 SpectraMax iD3(Molecular Devices)微孔板读板机检测 ADCC 发光信号强度,发现 Ipilimumab 的 ADCC 活性很弱,而...
植物源抗 CTLA-4 抗体的表达及功能验证:癌症免疫治疗的新希望 《Plant Biotechnology Reports》:Expression and in vitro function of anti-CTLA-4 human antibody expressed in plants 编辑推荐: 为探究植物系统生产生物仿制药的潜力,研究人员开展表达抗人 CTLA-4 抗体伊匹木单抗(Ipilimumab)的研究。结果显示,纯化的 ...
此项来自英国伦敦大学学院癌症研究所的研究清楚地表明,对高免疫原性的肿瘤,通过优化抗体的Fc片段,或者采用高亲合力的Fc受体突变体,可以增强抗体依赖的细胞介导的细胞毒性(antibody-dependent cell-mediated cytotoxicity,ADCC),从而明显改善CTLA-4抗体的治...
1.Xin Gana, Qianqian Shana, He Li et al.An anti-CTLA-4 heavy chain–only antibody with enhanced Treg.PNAS 2022 2.和铂医药官网 3. 天演药业官网 4.Peter S. Lee, Katherine G. MacDonald, Evan Massi et al. Improved therapeutic index...
Description: The 14D3 monoclonal antibody reacts with human CD152, also known as cytotoxic T lymphocyte antigen-4 (CTLA-4). CTLA-4, a protein with structural similarities to CD28, is expressed on activated T cells (activated B cells may also express CTLA-4) and binds the B7 family members...
- 产品规格 宿主/亚型 Mouse / IgG2a, kappa 分类 Monoclonal 类型 Antibody 克隆号 BNI3 抗原 Human CD152 偶联物 APC 激发/发射光谱 651/660 nm查看光谱 形式 Liquid 保存条件 4° C, store in dark 运输条件 Wet ice RRID AB_2536113 产品详细信息 ...