型号: Csf1r-(IRES-iCre)小鼠 参考报价: 销售商: 上海南方模式生物科技股份有限公司 总点击数: 1745 更新日期: 2024-11-19 产品类别: 实验动物 性能参数 验证数据 图1.流式检测Csf1r-Cre+/-;R26-mTmG+/-小鼠外周血巨噬细胞中荧光基因的表达。在cre表达的F4/80巨噬细胞中,tdTomato被切掉,细胞...
将IRES-iCre共表达结构插入到小鼠Csf1r基因终止密码子处。 应用领域:Cre工具鼠 *使用本品系发表的文献需注明: Csf1r-IRES-Cre mice (Cat. NO. NM-KI-190026) were purchased from Shanghai Model Organisms Center, Inc.. 验证数据 图1.流式检测Csf1r-Cre+/-;R26-mTmG+/-小鼠外周血巨噬细胞中荧光基因的...
作者分别在缺乏P53(PDG-p53 KD)和Ink4a/Arf(PDG-Ink4a/Arf KO)抑癌基因小鼠胶质瘤模型中进行分割放疗(2Gy/天,5天共10Gy);通过使用Flt3:Cre和Rosa26:mTmG髓系细胞谱系追踪模型。在该模型中,外周募集的MDM呈绿色荧光蛋白阳性(green fluorescent protein–positive,GFP+),而来自卵黄囊前体的MG呈GFP−,产生Frce。
与R26R~(EYFP)组比较,Csf1r-Cre~(ERT2)小鼠介导EYFP标记效率最高的是脑组织(P<0.001),最低的是胸腺组织(P<0.05),脾脏组织则差异无统计学意义.结论 成年Csf1r-Cre~(ERT2)小鼠与R26R~(EYFP)小鼠是获得Csf1r-Cre~(ERT2) R26R~(EYFP)诱导型条件性荧光小鼠的有效途径.Csf1r-Cre~(ERT2)介导EYFP可对小鼠...
Figure 2. Recombinant HEK293 cell line expressing firefly luciferase gene under the control of CRE response elements with constitutive expression of CSF1R(Colony Stimulating Factor 1 Receptor). Figure 3. Detect Luciferase assay by Promega Bright-Glo Luciferase Assay System. HEK293/CFS1R-SRE Luciferas...
值得注意的是,这项研究还为开发米诺环素作为小胶质细胞稳态调节剂,治疗患有ALSP发病高风险的CSF1R突变患者提供了强有力的治疗基础。
品系名:C57BL/6Smoc-Csf1rem1(flox)Gt(ROSA)26Sorem1(SA-FRT-2xpolyA-CAG-FRT-CreERT2-Rox-WPRE-Rox-polyA)Smoc 品系状态:在研 | 目录号:NM-CKO-234226 你也可能感兴趣 Tamoxifen诱导Cre-ERT2小鼠 使用指南 Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢...
The numbers of lysozyme-expressing Paneth cells were unchanged in the intestinal crypts of Csf1rΔIEC mice compared to Vil1-Cre and Csf1rFL/FL transgenic control mice (Fig. 3g, h). Paneth cell morphology and expression of Defa1 were also unaffected in the intestines of Csf1rΔIEC mice (...
To our surprise, we discovered that the iDTR allele alone leads to the loss of CSF/ventricles phenotype following diphtheria toxin (Dtx) treatment independent of cre expression. To examine the underlying mechanism for the loss of CSF in the Cx3cr1-iDTR ablation and iDTR models, we additionally...
By contrast, CSF1R haploinsufficiency has been shown to decrease the phagocytosis capacity of beads or amyloid-β in peripheral macrophages, but not microglia, isolated from Csf1rflx/wt; Cx3cr1Cre/+ mice [46]. Our study shows that primary Csf1r+/− microglia displayed no obvious changes in...