A cerebrospinal fluid (CSF) Alzheimer's disease (AD) profile, that is, decreased amyloid-β1-42 (Aβ42) and increased total tau protein (t-tau) and/or phosphorylated tau at threonine-181 (p-tau),1 has been identified in a substantial number of dementia with Lewy bodies (DLB) patients...
The aim of this study was to investigate the diagnostic accuracy of three potential CSF biomarkers, total tau protein (t-tau), tau protein phosphorylated at threonine 181 (p-tau181), and tau protein phosphorylated at serine 199 (p-tau199) in the differential diagnosis of AD and FTLD ...
Buerger K., Zinkowski R., Teipel S. J., Tapiola T., Arai H., Blennow K., et al. CSF tau protein phosphorylated arthreonine 231 in the differential diagnosis of Alzheimer’s disease.Submitted, 2001. Hesse C., Rosengren L., Andreasen N., Davidsson P., Vanderstichele H., Vanmechelen...
Objective: Recently, we found CSF tau protein and serum creatine kinase (CK) concentration changes related to the stage of the disease in a smaller series of 20 patients with Amyotrophic lateral sclerosis (ALS). Furthermore, several studies have demonstrated the presence of inflammatory infiltrates ...
CSF levels of β -amyloid 1-42, tau and phosphorylated tau protein in CADASIL. European Journal of Neurology . 2008; 15 (11):1252–1255.Formichi P, Parnetti L, Radi E, Cevenini G, Dotti MT, Federico A. CSF levels of beta-amyloid 1-42, tau and phosphorylated tau protein in ...
The NT-PD patients were found to have significantly higher levels of CSF tau protein and index tau/beta than the control subjects and other Parkinsonian subgroups, but no significant differences in these markers were found between AD and NT-PD patients. In the context of more rapid clinical ...
研究利用人类诱导多能干细胞(iPSC)技术,诱导干细胞分化成神经元,并在这些神经元中表达了与疾病相关的tau(Microtubule-associated protein tau,MAPT )蛋白变异形式。通过这种方式,研究人员在实验室环境中模拟了大脑疾病的发展,并观察到了tau蛋白聚集物的形成和扩散,揭示了tau蛋白传播与一种名为UFMylation的细胞过程之间...
Tau protein levels did not correlate with cognitive measures. CONCLUSION CSF Aβ levels are altered in a subset of patients with early PD and relate to memory impairment. Our study suggests that alterations in Aβ protein metabolism...
Advances in the development of biomarkers for Alzheimer's disease: from CSF total tau and Abeta(1-42) proteins to phosphorylated tau protein. the development of biomarkers for Alzheimer‘s disease: from CSF total tau and Abeta(1-42) proteins to phosphorylated tau protein.Brain Research Bulletin...
蛛网膜下腔阻滞穿刺成功后留取CSF 2～3 ml,采用ELISA法测定CSF INS、Aβ42、总tau蛋白(total tau protein, t-tau)和磷酸化tau蛋白(phosphorylated tau protein,p-tau)。收集术前1 d血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)等生化指标。