PURPOSE:To provide CSF-1 gene promoter useful for animal cell manifestation system. CONSTITUTION:Human chromosome DNA is extracted from human liver cell, human peripheral leukocyte, etc., partially digested with a proper restriction enzyme and introduced into a proper phage vector (e.g. lambdagt10...
The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase th...
赛业生物专栏《Gene of the Week》每周二会根据热点研究领域介绍一个基因，详细为您介绍基因基本信息、研究概况和应用背景等，助您保持学术研究敏锐度，提高科学研究效率，期待您的持续关注哦。今天我们要讲的主角是脑白质病的重要元凶——CSF1R。基因基本信息 CSF1R中文名称为集落刺激因子1受体，也可以称为CD115，控...
近期,首都医科大学附属北京天坛医院徐俊教授团队发表题为“Two Novel Intronic Mutations in the CSF1R Gene in Two Families With CSF1R-Microglial Encephalopathy”的文章。 该研究首次报道了两个新发内含子剪切突变的独立CSF1R小胶质细胞脑病家系,详细描述各家系遗传、临床、多模态影像特征,提出CSF1R小胶质细胞脑病新...
表1部分CSF1R基因突变及潜在机制Tab.1PartialCSF1Rgene mutation and potential mechanism 图2CSF1R基因突变致ASLP发病的机制图 A. 显性负性效应:突变型CSF1R可以自行或与野生型CSF1R组装成无功能的二聚体受体,导致信号无法向下转导。B. 功能缺失:CSF1R的酪氨酸激...
想获得论文选题思路,提高发文命中率?你需要了解学科发展态势和未来走向!赛业生物专栏《Gene of the Week》每周二会根据热点研究领域介绍一个基因,详细为您介绍基因基本信息、研究概况和应用背景等,助您保持学术研究敏锐度,提高科学研究效率,期待您的持续关注哦。今天我们要讲的主角是脑白质病的重要元凶——CSF1R。
exerts paracrine effects on osteoclasts and can interact with CSF1R. M-CSF is a four α-helical bundle cytokine and its active form is found extracellularly as a disulfide-linked homodimer. Four transcript variants encoding three different isoforms have been reported for M-CSF gene. Although forms...
A novel dominant-negative mutation of the CSF1R gene causes adult-onset leukoencephalopathy with axonal spheroids and pigmented glia[J]. Am J Transl Res,2019,11(9):6093-6101. [7] van Gerpen JA,Wider C,Broderick DF,et al. Insights into the dynamics of hereditary diffuse leukoencephalopathy ...
All rights reserved. Colony-Stimulating Factor-1 (CSF-1) XU-MING DAI AND E. RICHARD STANLEY Albert Einstein College of Medicine, New York I. INTRODUCTION II. CSF-1 GENOMIC ORGANIZATION, GENE EXPRESSION, BIOSYNTHESIS, AND STRUCTURE http-equiv="content-type" ...
Gene Typenonsense_mediated_decay Uniprot IDP07333.2 Pathway/LibraryKinases Library Gene SummaryThe protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all...