(iv)激活结构域.在体外和体内,这种抗CS1抗原的scFv片段可用于构建本发明的CART细胞——其可针对CS1抗原阳性靶细胞特异性分泌高水平细胞因子IFNγ,并对CS1抗原阳性靶细胞具有特异性杀伤作用.该抗CS1单克隆抗体,其单链可变片段(scFv)及其CAR融合蛋白以及CAR表达T细胞(CART)或NK细胞(CARNK)可广泛应用于CS1抗原阳性的...
Fig. 1: High-throughput generation and screening of BCMA/CS1 OR-gate CARs. aA vertically integrated optimization process for CAR-T cell therapy development.bSchematic of a single-chain bispecific (OR-gate) CAR, which contains two ligand-binding domains connected in tandem. A panel of CAR varia...
本发明提供一种多发性骨髓瘤合并慢性移植物抗宿主病(cGVHD)小鼠模型的建立方法,依次包括以下步骤:以NODSCIDIL2rg/小鼠作为模型小鼠;小鼠接受全身辐照100cGy后,将多发性骨髓瘤荧光素酶报告基因细胞株(IM9)悬液注射至小鼠;小鼠接受注射后8天,将CS1CART细胞悬... 翁建宇,陈晓梅,杜欣,... 被引量: 0发表: 2022年...
Cellectis公司通过使用TALEN基因编辑技术在引入CS1 CAR之前从T细胞中剔除CS1基因,解决了这个问题。 Cellectis公司的异基因CAR-T细胞产品系列采用通用型CART(UCART)生产工艺,可产生冷冻的、现成的、同种异体的工程化CAR-T细胞。传统的CAR-T疗法需要从患者体内提取T细胞,通过工程化插入嵌合抗原受体(CAR),使T细胞能够靶向癌细...
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