Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites. Nat. Struct. Biol. 1998, 5, 827-835.Curry, S., Mandelkow, H., Brick, P., Franks, N. (1998) Crystal structure of human serum albumin complexed with fatty acid reveals ...
States that the three-dimensional structure of human serum albumin has been determined crystallographically to a resolution of 2.8 angstroms. Where the pri... M Xiao,Carter,C Daniel - 《Nature》 被引量: 2072发表: 1992年 Implications of the three-dimensional structure of alpha 1-antitrypsin for ...
Although a high resolution structure of human serum albumin was published some years ago (13), the unavailability of the three-dimensional coordinates did not encourage others to extend this work. Curry et al. (14) subsequently published a high resolution structure of the protein that identified ...
The crystal structure of the title compound, L-(S)-tryptophane D-(R)-mandelate 1.5 hydrate, (I), has been determined. The structure shows molecular recognition in diastereomer salt. In the crystal packing, the hydrophobic and hydrophilic layers were well separated along the a-xis. One water...
Crystal structure analysis of warfarin binding to human serum albumin: anatomy of drug site I. Human serum albumin (HSA) is an abundant transport protein found in plasma that binds a wide variety of drugs in two primary binding sites (I and II) and c... I Petitpas,AA Bhattacharya,S Twin...
Here, we report the crystal structure of human CB2 in complex with a rationally designed antagonist, AM10257, at 2.8 Å resolution. The CB2-AM10257 structure reveals a distinctly different binding pose compared with CB1. However, the extracellular portion of the antagonist-bound CB2 shares a ...
This structure of Ssp revealed that it is composed of an N-terminal subtilisin-like protease domain and a C-terminal three-stranded β-helical domain (Fig.1b). The subtilase domain of Ssp is positioned directly on top of the β-helical domain, essentially capping the β-helical scaffold (Fi...
In this study, we solved the crystal structure of human METTL6 in complex with S-adenosyl-L-homocysteine (SAH) at 1.9 Å and characterized the association mode between the enzyme and the cofactor. By structural comparison and modeling studies, we analyzed the possible binding mode of the...
Effect of heme structure on 02-binding properties of human serum albumin-heme hybrids: Intramolecular histidine coordination provides a stable O2: Adduct complex 5,10,15,20-Tetrakis[(α,α,α,α-o-pivaloylamino)phenyl]porphinatoiron(II) and 5,10,15,20-tetrakis-{[α,α,α,α-o-(1-methyl...
The structure of NUDT15 is similar but distinct from MTH1 Although NUDT15 is similar in sequence to MTH1, we have demonstrated that NUDT15 has a remarkably low activity towards 8-oxo-dGTP. To gain insight into the substrate preference of NUDT15, we determined the structure of the human NUD...