3. 肿瘤上PD-L1的高表达:肿瘤上高表达的某些配体如PD-L1,会抑制抗肿瘤T细胞的应答。多种机制可能导致PD-L1高表达,包括PTEN的缺失或PI3K/AKT的突变,EGFR突变,MYC过表达,CDK5基因破坏以及PD-L1基因3’-UTR的截短。目前还不知道PD-L1的高表达是否会对anti-PD-1/PD-L1的响应有影响,但是它会影响其他的肿瘤免疫...
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