Our study describes breast cancer risk loci using a cross-ancestry GWAS approach. We first identify variants that are associated with breast cancer at P < 0.05 from African ancestry GWAS meta-analysis (9241 cases and 10193 controls), then meta-analyze with European ancestry GWAS data (122977 ...
Byun, J., Han, Y., Li, Y.et al.Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer.Nat Genet54, 1167–1177 (2022). https://doi.org/10.1038/s41588-022-01115-x ...
Fig. 2: Mirrored Manhattan plots of GWAS and TWAS in the cross-ancestry meta-analysis and comparison of the variant effect sizes for each ancestry-specific meta-analysis. aGWAS and TWAS mirrored Manhattan plots for cross-ancestry study. The upper plot represents the GWAS result, and lower plot...
Fig. 2: Manhattan plot of the cross-ancestry meta-analysis for PUD. Two-sidedPvalues were derived from the cross-ancestry meta-analysis of 52,032 cases and 905,344 controls of EAS or EUR ancestry. Meta-analysis was performed using the IVW method under the fixed-effect model. For variants...
68. CROSS-ANCESTRY META-ANALYSIS OF OPIOID USE DISORDER UNCOVERS NOVEL ASSOCIATED LOCIdoi:10.1016/j.euroneuro.2021.07.157Rachel KemberRachel Vickers-SmithHang ZhouSylvanus ToikumoChristopher RentschHeng XuEmily HartwellRichard CristAmy JusticeKyle Kampman...
We conducted a large multi-ethnic meta-analysis of genome-wide association studies for primary open-angle glaucoma (POAG) on a total of 34,179 cases vs 349,321 controls, and identified 127 independent risk loci, almost doubling the number of known loci for POAG. The majority of loci have ...
genetics and addiction, GWAS, cross-population meta-analysis, psychiatric genetics, principal component analysis, Mahalanobis distance, genetic ancestryBackground and ObjectivesGiven moderate heritability and significant heterogeneity among addiction phenotypes, successful genome-wide association studies (GWAS) are...
Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. In addition to adding support for
analysis, some multiethnic loci contained variants near genome-wide significance in at least one other ancestry-specific meta-analysis with some nominal significance (P < 0.05) in the remaining ancestry-specific meta-analyses (Supplementary Table3). For example, rs7899503 inJMJD1Cwas significantly...
model66. The genome-wide significant associations that should have (i) meta-analysisP < 5 × 10−8/n, wherenis the number of proteins or peptide precursors used for the analysis; (ii)P < 0.05 in four sub-cohorts; (iii) consistent direction of effect across the sub-...