MAGENTA是一款计算工具,利用全基因组遗传数据,计算预先设定的涉及生物过程或者功能性基因集在遗传相关性的富集程度。开发的目的是分析基因型不是现成的数据集,比如大型的全基因组关联荟萃分析。在以下两种情况下可以使用:1,检验某个特定的假设;2,通过检测一系列已知的生物基因集(从不同的公共数据库提供的通路)提出某个...
Gene expres- sion meta-analysis identifies metastatic pathways and tran- scription factors in breast cancer[ J]. Bmc Cancer,2008, 8:394.M. Thomassen, Q. Tan, and T. A. Kruse, "Gene expression meta-analysis identifies metastatic pathways and transcription factors in breast cancer," BMC ...
Comprehensive Gene expression meta-analysis and integrated bioinformatic approaches reveal shared signatures between thrombosis and myeloproliferative diso... Comprehensive gene expression meta-analysis and integrated bioinformatic approaches reveal shared signatures between thrombosis and myeloproliferative disorders. ...
Although single-variant association analysis can be performed, it is grossly underpowered. Therefore, researchers have developed many RV association tests that aggregate multiple variant sites across a genetic region (e.g., gene), and test for the association between the trait and the aggregated......
An integrated gene expression meta-analysis of five independent publicly available microarray data of the three diseases was conducted to identify shared gene expression signatures and overlapping biological processes. Using INMEX bioinformatic tool, based on combined Effect Size (ES) approaches, we ...
Domschke K, Sheehan K, Lowe N, Kirley A, Mullins C, O’Sullivan R, Freitag C, Becker T, Conroy J, Fitzgerald M, Gill M, Hawi Z (2005) Association analysis of the monoamine oxidase A and B genes with attention deficit hyperactivity disorder (ADHD) in an Irish sample: preferential tran...
Although, systematic analysis of gene annotation is a powerful tool for interpreting gene expression data, it sometimes is blurred by incomplete gene annotation, missing expression response of key genes and secondary gene expression responses. These shortcomings may be partially circumvented by instead ma...
New techniques in sample preparation allow high throughput analysis of samples on the transcriptional as well as on the metabolic level. We present a service accessible via the web that allows the analysis of integrated data sets that combine gene-expression data and metabolic data. After uploading...
Meta-analysis of association of insertion/deletion polymorphism of angiotensin I-converting enzyme gene with diabetic nephropathy and retinopathy An insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene has repeatedly been shown to be associated with ischaemic heart di.....
Next, we conducted a meta-analysis to identify DE genes with a significant combined effect across CD4+T-cell populations in theDiscovery Set. For all DE genes at least 2 populations at the same time point of activation, we estimated a combined effect size by applying a random-effects model ...