华中农业大学农业微生物国家重点实验室李英俊团队近期在Engineering Microbiology杂志上发表了题为“CRISPR-based gene editing technology and its application in microbial engineering”的综述论文,系统梳理了不同CRISPR-Cas系统的原理以及其在微...
Application of the CRISPR/Cas9-based gene editing technique in basic research, diagnosis, and therapy of cancer. Molecular Cancer, https://doi.org/10.1186/s12943-021-01431-6 [3] Gong et al., (2022). CRISPR/Cas-Based In Vitro Diagnostic Platforms for Cancer Biomarker Detection. Analytical ...
CRISPR-based gene editing is widely implemented in various cell types and has great potential for molecular therapy.1 The CRISPR-Cas9 system creates sequence-specific double-strand DNA breaks that are repaired by a dominant error-prone nonhomologous end-joining (NHEJ) pathway, often resulting in ge...
[3] Wu S H, Li X, Qin D D, et al. Induction of core symptoms of autism spectrum disorder by in vivo CRISPR/Cas9-based gene editing in the brain of adolescent rhesus monkeys. Sci Bull, 2021, 66(9): 937-946 [4] Chen Y, Yu J, Niu Y, et al. Modeling Rett syndrome using TALE...
[1] Key questions (and answers) about the historic approval of a CRISPR-basedmedicine. Retrieved November 17, 2023 from https://www.statnews.com/2023/11/16/crispr-vertex-sickle-cell-beta-thalassemia-casgevy-approval/ [2] UK first to approve CRISPR treatment for diseases: what you need to...
7Sato, M. et al. The combinational use of CRISPR/Cas9-based gene editing and targeted toxin technology enables effiding of human antibodies to cells from GGTA1/CMAH knockout pigs. Am J Transplant 14, 1895-1900, doi:10....
[3] Teng M, Yao YX, Nair V, et al.Latest Advances of Virology Research Using CRISPR/Cas9-Based Gene-Editing Technology and Its Application to Vaccine Development[J].Viruses (2021)13 (5):779 [4] Kwart D, Gregg A, Scheckel C, et al. A large panel of isogenic APP and PSEN1 mutant ...
CRISPR-based drugs can theoretically manipulate any genetic target. In practice, however, these drugs must enter the desired cell without eliciting an unwanted immune response, so a delivery system is often required. Here, we review drug delivery systems
近日,意大利锡耶纳大学,医学、外科和神经科学学院的 Federica Nardi和Laura Pezzella等人在European Journal of Immunology期刊上发表了题为Assessing gene function in human B cells: CRISPR/Cas9-based gene editing and mRNA-based gene expression in healthy and tumor cells 的技术报道类研究论文。在本研究中,作者...
Vertex Pharmaceuticals宣布,欧盟委员会(EC)已授予其CRISPR/Cas9基因编辑疗法Casgevy(exagamglogene autotemcel,exa-cel)有条件上市许可,用于治疗12岁及以上镰刀型细胞贫血病(SCD)伴复发性血管闭塞危象(VOCs)患者,以及无法获得人类白细胞抗原(HLA)匹配造血干细胞移植治疗的输血依赖性β地中海贫血(TDT)患者。根据新闻稿...