When patients without a Dex level were excluded from the analysis (n=74), the sensitivity did not change but specificity and accuracy of Dex-CRH test further increased to 97% and 99%, respectively. Conclusion: The CRH test addition to the 2-day LDDST provided additional case detection in ...
33. Clerico A, Ripoli A, Zaninotto M, et al. Head-to-head comparison of plasma cTnI concentration values measured with three highsensitivity methods in a large Italian population of healthy volunteers and patients admitte...
We have confirmed the relatively high sensitivity of the DEX/CRH test in Japanese patients with depressive disorder (Oshima et al, 2000; Kunugi et al, 2004). These findings indicate that the DEX/CRH test is a useful laboratory tool to monitor HPA axis abnormalities in depressed patients in ...
Modifiable psychological factors may amplify or inhibit HPA axis activity in pharmacological activation paradigms, including CRH stimulation tests. The factors manipulated by the CI (novelty/familiarity, control and coping) may have particular salience to the HPA axis. Differential sensitivity to such ...
Sensitivity0.1 ng/ml Detection Range0.016-10 ng/ml Recommended Dilution (Serum/Plasma)Human: 4X / Mouse: 2X / Rat: 2X Estimated Lead Time1-2 business days Shipping TypeBlue ice Storage-20°C Introduction Corticotropin-releasing factor (CRF) (also known as Corticotropin-releasing hormone (CRH) ...
Influence of sex and corticotropin-releasing factor pathways as determinants in serotonin sensitivity. Endocrinology 150: 3709–3716. Michalon A, Koshibu K, Baumgartel K, Spirig DH, Mansuy IM (2005). Inducible and neuron-specific gene expression in the adult mouse brain with the rtTA2S-M2 ...
Sensitivity and specificity of the CRH test were 78% and 90%, respectively, and 86% and 92% for basal cortisol, respectively, using an optimal cutoff of 220nmol/L. Eight patients had false-negative test results with the CRH test (normal test but adrenal insufficient at follow-up), and ...
These doses of CRH have been previously used in mice to test pituitary sensitivity to CRH =-=[41]-=-. There were 7–8 mice in all groups at the end of the study. 2.8. ACTH and corticosterone radioimmunoassays Mice were decapitated, and the blood was collected in tubes containing sodium...
This ethogram is exquisitely sensitive to environment, but this sensitivity is muted by activation of PVN CRH neurons. New insights gained from approaches that establish causal links between innate behaviour and neural circuits are an Figure 6 | Photostimulation-induced grooming is sensitive to the ...
Stress leaves a lasting impression on an organism and reshapes future responses. However, the influence of past experience and stress hormones on the activity of neural stress circuits remains unclear. Hypothalamic corticotropin-releasing hormone (CRH) n