In 1998 a new formulation of the enteric coated pancreatin preparation Creon 10 000 MMS replaced the established 8000 ms. It contains smaller spheres of pancreatin (range 0.7–1.6 mm diameter) than the normal microspheres (range 1.0–2.0 mm), and is delivered in a 50% smaller capsule than Cr...
In a randomized, double-blind, multicenter, placebo-controlled trial, 27 patients with CP received four capsules of CREON (Creon 10; a pre-FDA mandate formulation with equivalent lipase content per capsule to current CREON 12,000 USP) with each meal (two capsules with snacks) for 2 weeks, ...