porcine pan-creatic tissue) corresponding to:Amylase 18 000 Ph.Eur. units Lipase 25 000 Ph.Eur. units Protease 1 000 Ph.Eur. units Excipients (nonmedicinal ingredients):Pellet core: macrogol 4000Pellet coating: hypromellose phthalate, dimethicone 1000, triethyl citrate, cetyl alcohol Capsule: ...
The preference is likely to have been due to the smaller capsule size which was more acceptable, even though all patients studied had already been satisfactorily swallowing the larger Creon 8000 ms capsules for a period of time. The preference for Creon 10 000 MMS should have a beneficial ...
In a randomized, double-blind, multicenter, placebo-controlled trial, 27 patients with CP received four capsules of CREON (Creon 10; a pre-FDA mandate formulation with equivalent lipase content per capsule to current CREON 12,000 USP) with each meal (two capsules with snacks) for 2 weeks, ...
2.1.1. Capsule Fill Weight The mean content weight of 10 capsules was determined for Kreon® and Lipancrea®. The results are shown in Table 1. Table 1. Capsule fill weight (n = 10). 2.1.2. Particle Imaging and Size Determination The width of both Kreon® drug products was abou...