2022年,中南大学湘雅医院等单位的相关研究人员在《Cell Death & Disease》(IF: 8.5)上发表了题为“CPT1A-mediated fatty acid oxidation promotes cell proliferation via nucleoside metabolism in nasopharyngeal carcinoma”的研究论文,确定...
研究表明,肿瘤细胞可通过加强对外界脂肪酸(FAs)的吸收以增强细胞的脂肪酸氧化降解(fatty acid oxidation,FAO)从而促使癌细胞在能量压力条件下生存[3,4],而细胞中脂肪酸的大量存在可诱导CPT1A的表达,同时引发线粒体的分裂[5]。作为细胞内FAO的关键限速酶,CPT1A在多种恶性肿瘤细胞中高表达并促进肿瘤的发生发展。有...
2022年,中南大学湘雅医院等单位的相关研究人员在《Cell Death & Disease》(IF: 8.5)上发表了题为“CPT1A-mediated fatty acid oxidation promotes cell proliferation via nucleoside metabolism in nasopharyngeal carcinoma”的研究论文,确定了肉碱棕榈酰转移酶1(CPT1)的致癌相关性,并阐述了从脂肪酸氧化(FAO)到细胞周...
2021年6月8日,美国麻省理工学院的研究人员在 Cell 子刊 Cell Reports 在线发表了题为:High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity 的研究论文。 该研究比以往任何时候都更详细地显示了高脂肪饮食如何引发一系列的分子级联事件进而导致肠道癌症的发生,为结直肠癌的发...
纤维化是慢性肾病(chronic kidneydisease,CKD)常见的病理形式。近年来代谢紊乱为阐述纤维化进展机制提供了新的视角。脂肪酸氧化(fatty acid Oxidation,FAO)的急剧减少致使小管间质能量衰竭,促进免疫细胞的浸润和肾脏纤维化。肉碱棕榈酰转移酶(carnitine p...
Fengqi Hao et al. Butyrate enhances CPT1A activity to promote fatty acid oxidation and iTreg differentiation. PNAS. 2021 118 (22) e2014681118; https://doi.org/10.1073/pnas.2014681118 版权声明 本网站所有注明“来源:生物谷”或“来源:bioon”的文字、图片和音视频资料,版权均属于生物谷网站所有。非经...
Fatty acid oxidation in the mitochondria is essential for energy homeostasis in the absence of a consistent energy supply, such as in prolonged fasting or exercise. Long-chain fatty acids, which make up the major dietary fraction of fatty acids, cannot enter the mitochondria by simple diffusion ...
sepsis. Proteomics analysis reveals enhanced expression of enzymes involved in fatty acid oxidation in following 4-octyl itaconate (4-OI) treatment in vitro. Downstream analysis reveals itaconate stabilizes the expression of the mitochondrial fatty acid uptake enzyme CPT1a, mediated by its hypo...
Anoikis is a critical obstacle to cancer metastasis. Colorectal cancer (CRC) exhibits a high rate of metastasis, leading to death, and the mechanisms involved in anoikis resistance are still unclear. We identified that the fatty acid oxidation (FAO) pathway was activated in detached CRC cells. ...
Fatty acid oxidation: An emerging facet of metabolic transformation in cancer 2018, Cancer Letters Citation Excerpt : For instance, 3- to 4-fold increases in expression of CPT-1 A, CPT-1B, and CPT-2 were observed in chronic lymphocytic leukemia (CLL) cells compared to normal stromal cells ...