CPT-11 has also been found to be active in leukemia, lymphoma, SCLC, non-small cell lung cancer, colorectal cancer, ovarian cancer, and cervical cancer. CPT-11 has also demonstrated schedule-dependent antitumor activity and toxicity in preclinical animal models. On this basis, we carried out ...
Small-cell lung cancerJCOGCPT-11Small-cell lung cancer (SCLC) accounts for approximately 15% of all cases of lung cancer and is a particularly aggressive form of lung cancer characterised by a poor prognosis, rapid tumour growth, and early metastasis. Roughly, two-thirds of patients with SCLC...
2. Qi, M. et al. AIM2 promotes the development of non-small cell lung cancer by modulating mitochondrial dynamics. Oncogene 39, 2707-2723, doi:10.1038/s41388-020-1176-9 (2020). 3. Nieman, K. M. et al. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor gro...
所述的癌症可以是例如肺癌,非小细胞肺(NSCL)癌,支气管细胞肺癌(bronchioloalviolar cell lung cancer),骨癌,胰腺癌,皮肤癌,头或颈癌,皮肤或者眼球内黑素瘤,子宫癌,卵巢癌,直肠癌,肛门区癌,胃癌,肠癌,结肠癌,乳腺癌,子宫癌,输卵管癌,子宫内膜癌,宫颈癌,阴道癌,外阴癌,霍奇金病,食道癌,小肠癌,内分泌系统癌,...
1. Patients are diagnosed as pancreatic cancer、gastric cancer、non-small cell lung cancer or colorectal cancer in cytodiagnosis or tissue diagnosis; 2. Patients show no response or relapse after a general standard chemotherapy; 3. Age 18-75 years old; 4. Performance Status score of 0 -2 ...
1 Despite the availability of molecular targeted therapies and immunotherapy for patients with lung cancer, recurrence and disease progression due to drug resistance are common.2 Cancer stem cells (CSCs), which are pivotal drivers of tumor initiation, resistance, and metastasis, play a critical role...
CPT-11 in combination with cisplatin for advanced non-small-cell lung cancer : Masuda N, Fukuoka M, Takada M, Kusunoki Y, Negoro S, Matsui K et al. Department of Internal Medicine, Osaka Prefectural Habikino Hospital, 3-7-1 Habikino, Habikino, Osaka 583. J Clin Oncol 1992;10:1775鈥...
Gly-7-MAD-MDCPT (compound 4b) 是一种抗癌剂。Gly-7-MAD-MDCPT 是一种喜树碱 (Camptothecin(HY-16560)) 化合物,对多种癌细胞有细胞毒性,IC50为 10-1000 nM。 MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务 我们将采用定制合成服务的方式为您快速提供所需产品和技术服务 ...
of the lung. The patient either sits in a chair or sits upright in bed and inhales, pushing the abdomen out to force maximum amounts of air into the lung. The abdomen is then contracted, and the patient exhales. Deep breathing exercises are done several times each day for short periods...
cancerl,smallcell lung cancer 2,lung adenocarcinomasca觥2,chemonativepatients4,previ— ously treated patients8)田塘re,menofgastrointestinal:CPT一1 l100mg/m2iv dI,d8:CF200mg/m2 iv2hd1.d2;d8,d9;5 一Fu 400mg/m2ivbolusfollowedby 5一FU600 ...