Ten treatment-related AEs (TRAEs) in 4 pts occurred with R monotherapy; 2 pts each had fatigue and vomiting. There were 64 TRAEs in 15 pts during combination therapy including rash (11) diarrhea (8), nausea (4),
Trastuzumab resistance has been becoming a major obstacle for treatment of HER-2-positive breast cancer patients. Increasing evidence suggests that mesenchymal stem cells (MSCs) play critical roles during the formation of drug resistance, however, the underlying mechanism is not well known. In this ...
Zhang C, Zhu H, Yang X, Lou J, Zhu D, Lu W, et al. P53 and p38 MAPK pathways are involved in MONCPT‐induced cell cycle G2/M arrest in human non‐small cell lung cancer A549. J Cancer Res Clin Oncol. 2010;136:437‐45....