CPSF6 (E4F5F) Rabbit mAb recognizes endogenous levels of total CPSF6 protein. Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu56 of human CPSF6 protein. ...
We also studied the relevance of different protein domains on subcellular localization, showing that the C-terminal domain is critical for nuclear localization. Collectively, our results showed that cpsf6 expression changes during early development and that the subcellular localization of the protein is ...
【纯化方法】:affinity purified by Protein A 【储存液】:0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 【产品应用】:not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user. ...
UniProt ID:(Human) Q16630,(Mouse) Q6NVF9 Entrez Gene ID:(Human) 11052,(Mouse) 432508 功能 nucleotide bindingRNA bindingmRNA bindingprotein bindingpoly(A) RNA bindingnucleic acid bindingRNA processing factor 参与通路 mRNA polyadenylationmRNA processingprotein tetramerization...
It is widely recognized that the PML-RARα protein can be degraded by ATRA, ATO, or their combination1,3. We also examined the expression of the CR fusions under these treatments. However, neither ATRA nor ATO, or their combination, induce degradation of the CR fusion proteins (Supplementary...
Related products Corresponding antigens APrEST81008 cleavage and polyadenylation specific factor 6, 68kDa PrEST Antigen CPSF6Recombinant protein fragment of Human CPSF6 2 432,0 kr In Stock (10+) Read more
The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other...
Downregulation of the CPSF6 protein, one of the 3′ end-processing factors, mediates APA in macrophages with responses to virus infection and plays an important role in its anti-virus effect. However, the signaling pathway and molecular mechanism underlying the downregulation of the CPSF6 protein ...
TNPO3 promotes HIV-1 infectivity indirectly, by shifting the CA-binding protein CPSF6 to the nucleus, thus preventing the excessive HIV-1 CA stability that would otherwise result from cytoplasmic accumulation of CPSF6. Similar content being viewed by others ...
Deregulated expression and subcellular localization of CPSF6, a circRNA-binding protein, promote malignant development of esophageal squamous cell carcinoma Objective:Cleavage and polyadenylation specific factor 6 (CPSF6) has been documented as an oncoprotein in different types of cancer. However, functions...