We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media. By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some...
(hsa_circ_0000417),of which depletion also resulted in cell cycle arrest and cell apoptosis in ESCC.Conclusions:These findings gave us insight that overexpression of cytoplasmic CPSF6 protein is associated with poor prognosis in ESCC and CPSF6 may function as an oncoprotein,at least in part,...
PF74 affects the restriction of MxB to HIV-1 Since release of CPSF6 by CA N74D mutation or CPSF6 RNAi eliminated MxB’s anti-HIV-1 function, we further tested the effects of PF-3450074 (PF74), a small inhibitor that directly binds the HIV-1 CA at a site also utilized by host cel...
CPSF6 is located in the nucleus to function as a 3′ end-processing factor, so how SYVN1 can interact and ubiquitinate became the question that should be resolved. P53 has also been found to be a substance of SYVN1, and overexpression of p53 and SYVN1 revealed that p53 predominantly co...
DevelopmentCPSF6 is a component of the CFIm complex, involved in mRNA 3鈥瞖nd processing. Despite increasing interest on this protein as a consequence of proposed roles in cancer and HIV infection, several aspects of CPSF6 biological function are poorly understood. In this work we studied the ...
Collectively, these findings establish a post-transcriptional mechanism of CPSF6 expression and describe a novel function of miR-125b in virus-host interaction.doi:10.1096/fasebj.2020.34.s1.03027Evan ChaudhuriSabyasachi DashMuthukumar Balasubramaniam
DevelopmentCPSF6 is a component of the CFIm complex, involved in mRNA 3'end processing. Despite increasing interest on this protein as a consequence of proposed roles in cancer and HIV infection, several aspects of CPSF6 biological function are poorly understood. In this work we studied the ...
While heterologous MCDs effectively substituted for CPSF6 MCD function during HIV-1 infection, Arg-Ser domains from related SR proteins were largely ineffective. While MCD-deleted and wildtype CPSF6 proteins displayed similar capsid binding affinities, the MCD imparted LLPS-dependent higher-order ...
By extension, our study emphasizes that different NLSs can have comparatively dramatic post-nuclear effects on host cargo function.Rohlfes, NicholasRadhakrishnan, RajalingamSingh, Parmit K.Bedwell, Gregory J.Engelman, Alan N.Dharan, Adarsh
Since the identification of TNPO3 as a factor required for HIV-1 infection many studies have attempted to understand the specific function of this karyopherin in viral replication. Experiments in this manuscript demonstrate that TNPO3 is not directly required for nuclear import of the viral PIC. ...