CpG-Stat3 siRNAICBMT: Oligonucleotides: Therapies and Applicationsimmune checkpoint blockadeimmunotherapyImmune checkpoint blockade (ICB) therapy has significantly benefited patients with several types of solid tumors and some lymphomas. However, many of the treated patients do not have a durable clinical ...
AIRISE-02 is a nanoparticle co-delivering STAT3 siRNA and CpG intratumorally, utilizing local tumor antigens to train the immune system to kill cancer throughout the body. AIRISE-02 shows strong efficacy in various tumor models, and favorable safety in mice and monkeys....
698. Eliminating TLR9+ Prostate Cancer Stem Cells In Vivo Using NF-kB/RELA- or STAT3-Targeting CpG-siRNA Conjugatesdoi:10.1016/s1525-0016(16)34307-6Molecular Therapy
Local administration of CpG-RELAsiRNA or CpG-STAT3siRNA but not control conjugates, inhibited tumor growth and cancer cell clonogenic potential in two xenotransplanted prostate cancer models. Selective elimination of tumor-propagating cells using TLR9-targeted blockade of NF-?B/RELA and STAT3 signaling...