Scopus BioPharma(SCPS)宣布,FDA已批准CpG-STAT3siRNA的研究性新药申请(IND),CpG-STAT3siRNA是治疗多种癌症的独特免疫肿瘤RNA疗法。其针对B细胞非霍奇金淋巴瘤的I期临床试验将在位于加利福尼亚州洛杉矶附近的癌症、糖尿病和其他危及生命疾病的独立研究和治疗中心“希望之城”启动。 CO-sTiRNA™基因治疗, 是一种双...
Furthermore, locally delivered CpG-Stat3 siRNA enhanced CD8+ Tcell tumor infiltration and antitumor activity in a xenograft tumor model. Overall, our studies in both B cell lymphoma and melanoma mouse models demonstrate the potential of combinatory immunotherapy with CpG-Stat3 siRNA and checkpoint ...
Local administration of CpG-RELAsiRNA or CpG-STAT3siRNA but not control conjugates, inhibited tumor growth and cancer cell clonogenic potential in two xenotransplanted prostate cancer models. Selective elimination of tumor-propagating cells using TLR9-targeted blockade of NF-?B/RELA and STAT3 signaling...
CpG-siRNA molecules delivered in silk spheres were observed inside the cells for longer time period than naked nucleic acid construct. Comparing with naked CpG-siRNA the prolonged silencing effect of Stat3 mRNA was induced when the CpG-siRNA constmct was delivered in silk spheres what also ...
AIRISE-02 is a nanoparticle co-delivering STAT3 siRNA and CpG intratumorally, utilizing local tumor antigens to train the immune system to kill cancer throughout the body. AIRISE-02 shows strong efficacy in various tumor models, and favorable safety in mice and monkeys....
We found that MLAA-34 siRNA was successfully delivered into THP-1 cells and induced MLAA-34 gene silencing via the blockade of JAK2/STAT3 and Wnt/-catenin signalling pathways. In addition, CpG(B)-MLAA-34 siRNA upregulated Gsk3尾 protein expression, resulting in retraining of the JAK2/STAT3 ...
We demonstrated that the combination therapy composed of CpG ODN and PD-1-siRNA delivered by attenuated Salmonella exhibited a strong ability to inhibit melanoma and improve the antitumor immune responses of tumor-bearing mice.doi:10.1016/j.intimp.2020.107052Xiaolong Jia...