This study evaluates the expression of the two isoforms COX-1 and COX-2 in a clinical model in which the surgical removal of impacted third molars is used to evaluate the analgesic activity of anti-inflammatory drugs. A 3-mm punch biopsy was performed on the oral mucosa overlying 1 impacted...
Epidemiological and clinical studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit cyclooxygenase (COX) slow the progression and delay the onset of Alzheimer disease (AD). Two isoforms of cyclooxygenase have been identified. Although much effort has recently been focused on ...
总说:我们前面已经讲了,对于非选择性的NSAIDs,其解热镇痛抗炎抗风湿的药理效果主要是由于抑制了COX2所产生的,而各种副作用主要是由于抑制了COX-1所产生的。所以,如果我们设计出“只能够抑制COX-2而不一致COX-1的药物”,就可以很大程度上减少NSAIDs药物的副作用。 →本类药物的代表要是三个:塞来昔布(celecoxib...
生物活性:Aspirin (Acetylsalicylic Acid) 是一种具有口服活性、有效且不可逆的环氧合酶COX-1和COX-2抑制剂,IC50值分别为 5 和 210 μg/mL。阿司匹林诱导细胞凋亡。阿司匹林抑制NF-κB的激活。阿司匹林还能抑制血小板前列腺素合成酶,可预防冠状动脉和脑血管血栓形成[1][2][3][4][5][6]。 IC50 和目标:IC50:...
COX-1 and COX-2 inhibitors 来自 NCBI 喜欢 0 阅读量: 77 作者: CJ Hawkey 摘要: By inhibiting prostaglandin synthesis, non-steroidal anti-inflammatory drugs (NSAIDs) cause mucosal damage, ulceration and ulcer complication throughout the gastrointestinal tract. The recognition that there are two ...
which is comparable to their precursors and higher than the well-known non-steroidal anti-inflammatory drug ibuprofen. Computational docking studies were performed to obtain and analyse putative models of the interaction of thiocanthal and thiocanthol with COX-1 and COX-2 binding sites. Predicted ...
COX-1 and COX-2 inhibition: Wish and reality of a specific therapy with non-steroidal antirheumatics 来自 ResearchGate 喜欢 0 阅读量: 25 作者:C Geisslinger,K Brune,M Goppeltstrube 摘要: Nonsteroidal anti-inflammatory drugs (NSAIDs) exert their anti-inflammatory action as well as most of ...
The role of COX-1 and COX-2 in Alzheimer's disease pathology and the therapeutic potentials of non-steroidal anti-inflammatory drugs. 来自 Semantic Scholar 喜欢 0 阅读量: 15 作者:J Hoozemans,M O'Banion 摘要: Epidemiological studies indicate that anti-inflammatory drugs, especially the non-...
(S)-Flurbiprofen_COX-1和COX-2抑制剂_51543-39-6_Apexbio
Based on structural differences in the active sites of COX-1 and COX-2, a new class of drugs has been developed that specifically inhibits COX-2 but not COX-1 activity. By preserving the synthesis of homeostatic PGs, these specific inhibitors of COX-2 provide the clinical benefits of non...