Cox-1 inhibitor:An agent that inhibits the action of the enzyme cox-1 (cyclooxygenase-1). The common anti-inflammatory drugs such as aspirin, ibuprofen, and naproxen block the action of both cox-1 andcox-2. Cox-1 inhibitors can reduce inflammation, but they may also decrease the natural p...
A number of drugs achieve selectivity by binding to this pocket, including presumptively rofecoxib and celecoxib. Others, such as meloxicam, may inhibit COX-2 by different mechanisms.Truly selective COX-2 inhibitors have been shown to have no effect on gastric mucosal prostaglandin synthesis, to ...
This paper focuses on the synthesis and the in vitro testing of dual COX-1/COX-2 inhibitors. Starting from structures of non-steroidal anti-inflammatory drugs (NSAIDs) the diaryl methanone element was chosen as a lead. Modifications were carried out on this scaffold to obtain potent inhibitors...
COX-1 and COX-3 inhibitors 来自 Semantic Scholar 喜欢 0 阅读量: 64 作者: R Botting 摘要: Low doses of aspirin reduce both pain and fever, whereas the anti-inflammatory action of aspirin requires a much higher dose. It is possible that inhibition of cyclooxygenase (COX)-1 is the major ...
The current work is focused on in silico modeling of COX-1 inhibitors with enhanced safety gastric profile. A 5-point pharmacophore model, atom-based 3D qu... Luminita,Crisan,Ana,... - 《Structural Chemistry》 被引量: 0发表: 2019年 Intradiscal Injection of Cox‐2, But Not Cox‐1 Inhib...
Cost-effectiveness of low dose corticosteroids versus non-steroidal anti-inflammatory drugs and COX-2 specific inhibitors in the long-term treatment of rhe... OBJECTIVE: Non-steroidal anti-inflammatory drugs (NSAIDs) are used in nearly every patient with rheumatoid arthritis (RA) as part of a co...
(redirected from Inhibitors of COX2)Also found in: Thesaurus, Medical. COX-2 inhibitor n. Any of a class of nonsteroidal anti-inflammatory drugs that selectively block prostaglandin formation so as to cause minimal gastrointestinal side effects. American Heritage® Dictionary of the English ...
COX-1–Sparing NSAIDs—Is the Enthusiasm Justified? enthusiasm for selective COX-2 inhibitors has faded away due to the emergence of serious side effects associated with the long-term use of these NSAIDs... Peterson,Walter L. - 《JAMA The Journal of the American Medical Association》 被引量...
(S)-Flurbiprofen_COX-1和COX-2抑制剂_51543-39-6_Apexbio
It is possible, however, that NSAIDs, and more specifically COX-2 inhibitors, may be of value in the treatment and prevention of some forms of human cancer (Lin et al., 2002). Moreover, studies on the treatment of canine tumours with the NSAID piroxicam (a non-specific COX-inhibitor) ...