said, "We are glad that our study provides reassuring evidence on the COVID-19 vaccination effectiveness. I really believe that OMOP Common Data Model and federated analytics are the future of real-world evidence research. Extensive efforts are required at the harmonization phase but once the data...
It is critically important to understand the vaccine effectiveness (VE) of COVID-19 vaccines among IC populations as recommendations are updated over time in response to the evolving COVID-19 pandemic. Areas covered A targeted literature review was conducted to identify real-world studies that ...
Vaccine effectiveness data against severe COVID-19 (points and whiskers for 95% CI) are shown for pre-Delta (top row, panels (A)–(D), Delta (middle row, panels (E)–(H)) and Omicron (bottom row, panels (I)–(L)) variants. Note that for panels (D) and (I), no effectiveness...
It was urgent and necessary to synthesize the evidence for vaccine effectiveness (VE) against SARS-CoV-2 variants of concern (VOC). We conducted a systematic review and meta-analysis to provide a comprehensive overview of the effectiveness profile of COVID-19 vaccines against VOC. Methods Publishe...
The foremost important vaccine characteristic influencing vaccine choice is adverse reactions (40.6%; 95% CI 39.3–41.9) of a vaccine and effectiveness threshold (35.1%; 95% CI 33.9–36.4). Conclusions The inter-regional and individual country disparities in COVID-19 vaccine hesitancy highlight the...
Data on effectiveness and protection duration of Covid-19 vaccines and previous infection against general SARS-CoV-2 infection in general populations are limited. Here we evaluate protection from Covid-19 vaccination (primary series) and previous infecti
“after a discussion with the FDA.” Instead, they planned to conduct the analysis after 62 cases. But by the time the plan had been formalized, there had been 94 cases of Covid-19 in the study. It’s not known how many were in the vaccine arm, but it would...
The COVID-19 vaccine has been a miraculous, life-saving advance, offering staggering efficacy in adults, and was developed with astonishing speed. The time from sequencing the virus to authorizing the first COVID-19 vaccine was so brisk even the optimists appear close-minded. Yet, simultaneously...
We expect that our conclusions on the utility of updating vaccines should generalize to any updated COVID-19 vaccine, not just the fall 2022 bivalent vaccine, but additional monitoring and study of the real-world effectiveness of an annual vaccine is still necessary, and we hope that the findin...
Analysis by the BCCDC continues to show the effectiveness of coronavirus vaccines, especially in protecting against severe illness, provincial health officer Dr. Bonnie Henry said in her monthly research update Tuesday. That trend is also showing up with the more than 500,000 people who have recei...