The Clalit Research Institute, in collaboration with researchers from Harvard University, analyzed one of the world’s largest integrated health record databases to examine the effectiveness of the Pfizer vaccine against COVID-19. The study provides the first large-scale peer...
COVID-19 疫苗效力评估新视角:基于随机试验数据的检测阴性设计(TND)跨方案分析 《JAMA Network Open》:Evaluating the Test-Negative Design for COVID-19 Vaccine Effectiveness Using Randomized Trial Data: A Secondary Cross-Protocol Analysis of 5 Randomized Clinical Trials 编辑推荐: 本综述通过对 5 项Ⅲ 期...
While severe COVID-19 symptoms are extremely rare in infected children, they can pass on the virus to high-risk groups such as the elderly. That makes determining the effectiveness of a potential vaccine in children crucial, as vaccines work differently in kids and adults, t...
[2] Schrag SJ, Verani JR, Dixon BE, et al. Estimation of COVID-19 mRNA vaccine effectiveness against medically attended COVID-19 in pregnancy during periods of delta and omicron variant predominance in the United States....
Effectiveness against severe-to-critical disease was 92.9 percent and 87.6 percent, in the short-term follow-up and long-term follow-up, respectively. The waning of efficacy was small, indicating the COVID-19 vaccine protection against severe disease remains strong at six months, according to the...
13 For this reason, prospective studies of vaccine effectiveness in real-world scenarios post licensure are routinely needed. In the case of SARS-CoV-2, an efficacious vaccine might prevent infection, disease, or transmission (figure 1). The outcome of SARS-CoV-2 infection in individuals is ...
“We will follow more than 35,000 people living with HIV in both provinces to note COVID-19 vaccine uptake and rates of SARS-CoV-2 infection and hospitalization, which will allow us to study vaccine effectiveness in this population,” said Dr. Ann Burchell, associate professor at...
The mRNA-1273 (Moderna) vaccine was reported to have an efficacy of 94.1% at preventing symptomatic COVID-19 due to infection with ‘wild-type’ variants in a randomized clinical trial. Here, we assess the real-world effectiveness of this vaccine against SARS-CoV-2 variants of concern, ...
be safe and highly effective in reducing severe COVID-19, hospitalizations and mortality; however, despite available evidence on effectiveness reported COVID-19 vaccination coverage among older adults has not yet come close to the WHO goal of 100% in many parts o...
also announced similar effectiveness of its own COVID-19 vaccine candidate, which is made with the same, brand-new technology — using a snippet of the genetic code of the coronavirus to train the body to recognize if the real virus comes along. For both, “there’s every reason to be ...