In conclusion, Allium sativum may be an acceptable preventive measure against COVID-19 infection to boost immune system cells and to repress the production and secretion of proinflammatory cytokines as well as an adipose tissue derived hormone leptin having the proinflammatory nature....
最近仍在进行的一项II期研究(NCT04374461)旨在评估NAC(iv;6克/天)给药对COVID-19严重症状患者的影响;其结果将有助于阐明该药物对COVID-19患者的潜在治疗特性[63]。 此外,一项病例报告研究表明,口服和静脉注射2000mgGSH,均可有效缓解COVID-19的严重呼吸...
最近的研究表明,严重COVID-19可发展为急性呼吸窘迫综合征(ARDS),这是肺纤维化的主要诱发因素,不可逆转地损害呼吸功能。COVID-19最严重的后遗症主要表现在气道,应该首选将药物直接吸入肺部,因为可以降低使用剂量和全身副作用。尽管需要进一步研究来优化这些技术,最近的研究还显示了体外模型对于重建SARS-CoV-2感染和...
with one sample below the lower normal limit at day 42. Similarly, serum sodium levels also decreased following vaccination, indicative of vaccine influences on electrolyte balance. Again, electrolyte imbalance has also been ...
A study on ~200 hospitalized individuals with severe COVID-19 in China showed that this drug had no clear effect on disease outcome [12]. Still, it may be too soon to rule out lopinavir as a potential treatment, since it may be more effective for treating COVID-19 at an earlier stage...
COVID-19患者主要表现为呼吸系统症状,重症患者还可合并肺外多器官功能损伤。人体免疫系统可有效抵御病毒入侵,然而多项临床现象和病理解剖提示COVID-19患者病程中存在免疫应答失衡。免疫失衡和过度的炎症激活与COVID-19患者的疾病进展、不良预后密切相关。本文从机体固有免疫、适应性免疫、细胞因子风暴等角度综述了COVID-...
The serum of COVID-19 infected individuals was of interest as it is the part of our blood that contains crucial information about our immune system. Analysis of the serum made it possible to create a detailed timeline of the level of ‘neutralizing antibodies’ produced against COVID-19 infect...
In this review, we summarize the immune characteristics of COVID-19 and discuss the potential mechanisms of SARS-CoV-2-induced immune changes, their effect on disease outcomes, and their implications for potential COVID-19 treatments. The immunopathology of COVID-19 It has been shown that SARS...
Most COVID-19 vaccines are designed to elicit immune responses, ideally neutralizing antibodies (NAbs), against the SARS-CoV-2 spike protein. Several vaccines, including mRNA, adenoviral-vectored, protein subunit and whole-cell inactivated virus vaccines, have now reported efficacy in phase III trial...
They speculated that COVID-19 infection resulted in a heightened immune system response that was further stimulated by the recurring P. aeruginosa infections. This led to bystander activation of T cells specific for antigens unrelated to either SARS-CoV2 or P. aeruginosa, which caused the more ...