deletionclinical phenotypeinterferonThe SARS-CoV-2 virus, the causative agent of COVID-19, is undergoing constant mutation. Here, we utilized an integrative approach combining epidemiology, virus genome sequencing, clinical phenotyping, and experimental validation to locate mutations of clinical importance....
We previously demonstrated that 25-hydroxycholesterol (25HC), the metabolic product of the IFN-I inducible cholesterol 25-hydroxylase, is a broad-spectrum antiviral agent against numerous types of viruses, including SARS-CoV-263. In this manuscript, we provide evidence that inhibitors of FASN can ...
Informed consent was obtained from all vaccinated study participants before enrolment in the approved study by the Ethics committee of HCFMUSP. Regarding the control of samples used in this manuscript—patient consent was waived by the Ethics Committee of the UFABC since pre-pandemic samples were ob...