proprotein convertase subtilisin/kexin type 9, which would normally increase levels of circulating LDL-cholesterol. In 2022, the FDA approved Vutrisiran, a next generation hATTR treatment with enhanced uptake, shortening the dosing requirement from once every 3 weeks with Patisiran to once a quarter ...
In fact, the conjugation of the PDZ2 domain to polymeric nanoparticles increases the affinity toward the E protein effectively creating a “molecular sponge” able to sequester E proteins within the intracellular environment of infected cells. Our in vitro studies on selected cellular models, show ...
This sustained shedding may also be driving the cryptic transmission of the Beta VOC we observe in wastewater but since we have no longitudinal shedding data from the HIV patient population this is only conjecture. ES is also identifying viral shed from the animal reservoir. Our work has shown ...
but the SARS-CoV-2 tropism in vivo is not very clear. Several scRNA-seq studies of BALF and sputum samples from COVID-19 patients have not detected an abundance of SARS-CoV-2 RNA in airway epithelial cells but have accidentally found viral RNA in immune cells, particularly macrophages and...
in the early phase of COVID-19, viral growth and propagation are the primary determinants driving disease progression or resolution. In the later phases, a hyperinflammatory response by the host is much more important in driving the disease than is viral replication [11,17]. This understanding ...
Type of HLA could also determine COVID-19 and PASC outcomes because of its role in triggering autoimmune reactions. For example, DRB1*15:01–DRB5*01:01–DQA1*01:02–DQB1*06:02 are overrepresented in patients with multiple sclerosis while HLA-DRB1*03, HLA-DRB1*15, and HLA-DRB1*04 are ...
Sustained imports from international travel were a critical driving mechanism behind the observed number of non-Alpha cases. A phylogeographical analysis establishing the most parsimonious sets of monophyletic and exclusively domestic clades, which can be interpreted as individual introductions, confirmed that...
the disease [95]. These findings suggest that the involvement of a positive feedback loop among lung monocytes/macrophages and T cells, GM-CSF produced by expanded Trm17 cells, local complement activation, endothelial disruption, and vascular diseases may be specific in driving COVID-19 ...
It is also important to investi- gate the driving force behind this suddenly accelerated emergence of convergent RBD mutations, what such mutational convergence would lead to and how we can prepare for such rapid SARS-CoV-2 evolution. Antibody evasion by convergent variants First, we tested the ...
In this review we summarize what we think may be the factors driving this pattern between diabetes, aging and poor outcomes in respiratory infections. We also review therapeutic considerations and strategies for treatment of COVID-19 in diabetic patients, and how the additional challenge of this ...