A cost analysis shows that COVseq could be used to sequence thousands of samples at less than 15 USD per sample, including library preparation and sequencing costs. We conclude that COVseq is a versatile and scalable method that is immediately applicable for SARS-CoV-2 genomic surveillance and ...
c = xcov(x,y) returns the cross-covariance of two discrete-time sequences. Cross-covariance measures the similarity between a vector x and shifted (lagged) copies of a vector y as a function of the lag. If x and y have different lengths, the function appends zeros to the end of the...
2020年5月10日,University of Georgia/Utrecht University的Geert-Jan Boons课题组(下称“美国组”)在预印本网站bioRxiv上传了题为SARS-CoV-2 spike protein binds heparan sulfatein a length- and sequence-dependent manner的论文。研究者采用microarray的方法,分析了SARS-CoV-2 spike蛋白受体结合域(RBD)对不同HS...
这 3660 个转录本主要分布在内质网膜和核仁中。 在策略方面,首先,将每一条转录本划分为5'-非翻译区(5'-untranslated region, 5'-UTR)、编码区(coding sequence,CDS)和3'-非翻译区(3'-untranslated region, 3'-UTR)。随后统计k-mer的频数,比如 k=3 时,即三个碱基,有 64 种可能性,以其中一种可能性 A...
The sequences of BA7535 have been deposited in GenBank with the accession codes OP831943 and OP831944 for heavy chain and light chain, respectively. The other source data generated in this study are provided in the Supplementary Information and the Source Data file. Source data are provided ...
Two encode the large S sequence while the other two encode the smaller optimized receptor-binding domain (RBD) from S (Carlson 2020). The mRNA is then encapsulated in a lipid nanoparticle formulation. The novel design of the clinical trial allows for the simultaneous evaluation of safety, ...
已在原子水平上阐明了SARS-CoV S/ACE2界面,发现ACE2的使用效率是SARS-CoV传播能力的关键决定因素。SARS-CoV S蛋白和SARS-CoV-2 S蛋白具有大约76%的氨基酸序列一致性(sequence identity)。然而,人们仍不清楚SARS-CoV-2 S蛋白是否像SARS-CoV S蛋白那样使用ACE2和TMPRSS2进入宿主细胞。
This blog highlights one of the first studies identifying and characterizing the novel coronavirus, ultimately contributing to the viral genome sequence being shared worldwide. Screening for the novel coronavirus with one-step RT-qPCR Learn how researchers identified a novel, highly contagious coronaviru...
SARS-CoV-2 workflow for nanopore sequence data. Contribute to replikation/poreCov development by creating an account on GitHub.
Leveraging thousands of sequenced SARS-CoV-2 genomes, we performed a viral pangenome analysis to identify conserved genomic sequences. We used a rapid and highly efficient computational approach that relies on k-mers, short tracts of sequence, instead of conventional sequence alignment. Using this ...