4.9.3.1 1H NMR Spectrum The full 1H NMR spectrum of telmisartan is shown in Figure 4A–C with various regions being expanded for easier viewing. Confirmation of the spectral assignments was derived from a 2D DQF-COSY, and NESY experiment, see Figures 5A–D to 8A–C, respectively, and thes...
NMR-based determination of the pKaof protein side chains has been reviewed recently (Hass & Mulder, 2015;Platzer, Okon, & McIntosh, 2014). Because the typical pKaof Lys side chains is 10.5, Lys side-chain amino groups are usually protonated in the form ofNH3+in neutral and acidic pH ...
Full size image To further test the C2 proton exchange mechanism mediated by COSY, we performed the reciprocal H/D exchange experiment by assayingAtCOSY against the 2OHpCCoA substrate in 66% D2O. Consistent with the H/D exchange seen in the previous experiment using deuterium-labeled substrate,...
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Kibrik EJ, Steinhof O, Scherr G, Thiel WR, Hasse H (2012) 13C-NMR, 13C–13C gCOSY, and ESI-MS characterization of ether-bridged condensation products in N,N0-dimethylurea–formaldehyde systems. J Appl Polym Sci 128:3957Kibrik, E.J.; Steinhof, O.; Scherr, G.; Thiel, W.R.; ...