CT-FFR could reduce false-positive coronary CTA results, improving its gatekeeper function in this population, but more data is necessary.doi:10.1007/s00330-024-11211-7Leonie M. Beckerhttps://ror.org/01jvpb595grid.415960.f0000 0004 0622 1269Department of CardiologySt. Antonius Hospital Nieuwegein...
A hybrid approach integrating anatomical information from coronary CTA and functional information from FFR-CT or CTP holds potential for a comprehensive, accurate one-stop-shop CAD evaluation. However, further studies are needed to directly compare the utility of CTP with post-processing software tools...
CTA–derived fractional flow reserve The scientific basis of FFRCT computation has previously been described in detail (20). Standard coronary CTA datasets were transmitted for analysis (HeartFlow, Redwood City, California) (5). The 3-dimensional FFRCT model provides computed FFR values in all vessel...
Based on this technique, noninvasive fractional flow reserve (FFR) derived from CTA can identify lesion-specific ischemia by invasive coronary angiography (ICA)-derived FFR, as shown in several clinical trials (3–5). Nevertheless, CFD models are complex; involve multiple finely calibrated geometric...
Coronary CTA provides abundant information on coronary atherosclerosis beyond the assessment of coronary stenosis. With advanced processing technology, coronary CTA enables characterization of plaque subtypes and assessment of the hemodynamic significance of stenoses using CT-FFR, which further guides management...
The FFR is lowest in patients who have both stenosis ≥ 50% on coronary CTA and myocardial perfusion abnormalities and highest in patients with no significant stenosis and no myocardial perfusion defects. Among patients with discrepant results, FFR correlates better with myocardial perfusion ...
The article discusses the efficacy of coronary computed tomography angiography (CTA) for medical screening which allows the detection of coronary artery stenosis. It examines the standardization of coronary CTA with invasive coronary angiography. It also cites the use of coronary CTA in routine practice...
Another area for improvement is the complexity of the modeling utilized. While we used 3D simulations of coronary hemodynamics to compute FFR, the parameter estimation used 0D surrogate models that deviated from the true hemodynamics. In particular, 0D models do not accurately capture the flow with...
W. et al. Combined optical coherence tomography morphologic and fractional flow reserve hemodynamic assessment of non- culprit lesions to better predict adverse event outcomes in diabetes mellitus patients: COMBINE (OCT-FFR) prospective study. Rationale and design. Cardiovasc. Diabetol. 15, 144 (2016...
CTA FFR was computed using an on-site, clinician-operated application. Using binary regression, a single functional CT variable was created combining both CT MPI and CTA FFR. Finally, stepwise diagnostic work-up of CTA FFR with selective use of CT MPI was simulated. The diagnostic performance ...