Coronary artery disease (CAD), including its severe form, myocardial infarction (MI), is a common serious disorder, and a leading cause of death in industrial countries. The pathogenesis depends on multiple interactions on an environmental and genetic basis. As genetic heritability of CAD comprises...
心脏冠状动脉疾病(coronary artery disease, CAD)简称冠心病, 指冠状动脉粥样硬化使血管腔狭窄或阻塞和(或)因冠状动脉功能性改变(痉挛)导致下游心肌缺血缺氧或坏死而引起的心脏病, 亦称冠状动脉性心脏病(coronary heart disease, CHD)或缺血性心脏病(ischemic heart disease, IHD). 冠心病常见症状为心绞痛或胸闷胸痛,...
Coronary Artery Disease Genetics (C4D) Consortium. A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. Nat. Genet. 43, 339–344 (2011). IBC 50K CAD Consortium. Large-scale gene-centric analysis identifies novel variants for coronary...
Coronary Artery Disease Genetics (C4D) Consortium. A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. Nat. Genet. 43, 339–344 (2011). IBC 50K CAD Consortium. Large-scale gene-centric analysis identifies novel variants for coronary...
2015. Molecular genetics of coronary artery disease. J Hum Genet doi: 10.1038/jhg.2015.70.Ozaki K, Tanaka T. Molecular genetics of coro- nary artery disease. J Hum Genet 2016; 61: 71-7.Ozaki K and Tanaka T. Molecular genetics of coronary artery disease. Journal of human genetics. 2016;...
We report a genome-wide association study (GWAS) of coronary artery disease (CAD) incorporating nearly a quarter of a million cases, in which existing studies are integrated with data from cohorts of white, Black and Hispanic individuals from the Million Veteran Program. We document near equivalen...
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Because CAD is not a sudden-onset condition, but rather takes years to develop, there are several ways you can reduce your risk of developing the disease. Most revolve around what you eat and how much you move. “Coronary artery disease can be prevented with proper recognition and treatment ...
A large team of researchers affiliated with a host of institutions across Japan has identified multiple loci associated with ancestry-specific risk factors for coronary artery disease. In their paper published in the journalNature Genetics, the group describes their analysis of genetic information from ...
Coronary artery disease is the leading global cause of mortality. Long recognized to be heritable, recent advances have started to unravel the genetic architecture of the disease. Common variant association studies have linked approximately 60 genetic loci to coronary risk. Large-scale gene sequencing ...