More particularly, the present invention relates to ligand compounds adapted for chelating the free cupric ion in the serum of patients suffering from Alzheimer's and Wilson's diseases.Russo Vincenzo
We evaluated the capacity of copper(i) and copper(ii) chelators, including ammonium tetrathiomolybdate (ATTM), d-penicillamine (D-Pen), EDTA and trientine to interfere with macrophage activation. We also studied metformin, a biguanide used for the treatment of type-2 diabetes, because it can...
Therapeutic interventions include copper chelators (e.g., ammonium tetrathiomolybdate), and oxidative phosphorylation inhibitors like elesclomol and copper ionophores (CuII(atsm), CuII(gtsm), and disulfiram). These interventions modulate intracellular copper, elevate NO, and reduce inflammatory ...
First, copper chelators preferentially bind either cuprous or cupric. As a result, they potentially modulate copper redox-activity without removing copper from the system. Second, copper chelators are characterized as either membrane-permeable or -impermeable, thus would serve as an organ-selective ...
Copper chelators have been principally used in three aspects: (1) the understanding of the molecular basis for copper and copper-binding proteins in biological system, (2) the treatment for diseases due to alterations in copper metabolism and (3) the diagnostic application for copper metabolic ...
copper chelators; d-penicillamine; superoxide dismutase Abstract A subpopulation of familial cases of amyotrophic lateral sclerosis has been linked to mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1). There is in vitro evidence that certain SOD1 mutants, in addition to their normal...
Depletion of mitochondrial copper, which shifts metabolism from respiration to glycolysis and reduces energy production, is known to be effective against cancer types that depend on oxidative phosphorylation. However, existing copper chelators are too toxic or ineffective for cancer treatment. Here we de...
For example, some classic iron chelators have been widely used in the treatment of iron overload disorders, including deferasirox (DFX), deferiprone (DFP), deferitazole, desferoxamine (DFO) and triapine [144]. However, they have varying degrees of toxicity and limited therapeutic effects [145...
If you are being treated for Wilson disease or copper toxicity with drugs that bind copper (chelators), then your 24-hour urine copper levels may be high until body copper stores decrease. Eventually, blood copper and 24-hour urine copper levels should return to normal. ...
Copper, a strictly regulated trace element, is essential for many physiological processes including angiogenesis. Dysregulated angiogenesis has been associated with increased copper in tumors and thus copper chelators have been used to inhibit tumor angiogenesis. However, it remains unclear whether copper ...