copper; (3) neonates experiencing chronic diarrhea or malnutrition; (4) hospitalized patients undergoing long-term peritoneal dialysis; (5) severe burn patients; (6) renal dialysis patients; and (7) persons consuming large doses of supplemental zinc, antacids, or copper chelators (Prohaska, 2006...
Chelators such as triene (TETA), penicillamine, and desferrioxamine are safely used pharmacologically for the treatment of metal overload disorders, such as Wilson's disease. However, these molecules are hydrophilic and exert their effects by systemic depletion of metals, and do not pass across ...
Therapy is aimed at creating a negative copper balance with metal chelators, of which d-penicillamine is the most commonly used. d-penicillamine often causes gastro-intestinal side effects and life-long continuous therapy may lead to a deficiency of copper and zinc. The aim of the current ...
Hereditary copper-associated hepatitis in dogs resembles Wilson's disease, a copper storage disease in humans. Values for urinary copper excretion are well established in the diagnostic protocol of Wilson's disease, whereas in dogs these have not been evaluated. The objectives of this study were ...