Lung volumes in COPD: not only the total lung capacity.Obstructive sleep apneaAnimal modelAirway obstructionInflammationComment on Chest. 2010 May;137(5):1108-15. Chest. 1999 Jan;115(1):68-74.doi:10.1378/chest.10-0045Scarlata, Simone
Improvement in resting inspiratory capacity and hyperinflation with tiotropium in COPD patients with increased static lung volumes. BACKGROUND: In patients with COPD, changes in inspiratory capacity (IC) have shown a higher correlation to patient-focused outcomes, such as dyspnea with e... B Celli,...
长效β受体激动剂(long-acting beta agonist, LABA)和吸入性糖皮质激素治疗下,某些COPD患者仍会在数月中存在呼吸困难、活动受限和咳嗽等难治性症状,在慢性阻塞性肺疾病全球倡议(Global Initiative for Chronic Obstructive Lung Disease, GOLD...
During exercise, as ventilation increases, the increased EELV (dynamic hyperinflation) pushes tidal volume closer to total lung capacity (TLC) where expansion is limited by high pressures. IC decreases and breathing becomes so restricted that patients have to stop activity. RV=residual volume, IRV=...
In order to diagnose dLH two basic methodologies can be used: A) Serial measurements of IC to detect its changes, assuming stability of total lung capacity (TLC), and considering decreased IC as a reciprocal surrogate marker of increased FRC [17], [58], [59]. Contrarily to the ability of...
Objective: To investigate the correlation between the serum hypoxia-inducible factor-1伪, uric acid, inflammatory factor levels, and lung function in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Met... S Deng,T Zhu,Cen WangXinnan GuJun ZhangQin LuYan YangXi...
Pulmonary lung function can further be evaluated by measuring the lung volumes in a plethysmograph and by measuring the diffusion capacity of the lungs for carbon monoxide (DLCO). DLCO may be helpful to differentiate between asthma (usually normal or increased DLCO) and mild COPD (impaired DLCO ...
Increased retrosternal air space A long, narrow heart shadow Rapidly tapering vascular shadows accompanied by hyperlucency of the lungs Radiographs in patients with chronic bronchitis show increased bronchovascular markings and cardiomegaly Advantages of high-resolution CT include the following: Greate...
The key pathophysiological feature of COPD is undoubtedly expiratory airflow limitation, which may result in air trapping and lung hyperinflation, manifested as increased operating lung volumes and reduced Inspiratory Capacity (IC) and Inspiratory Reserve Volume (IRV)60 (Fig. 1). WBP uses Boyle’s ...
It was consistent with the study that eosinophils and basophils were present in all anatomical compartments of COPD-affected lungs and increased significantly in COPD from surgical lung tissue and biopsies. These data revealed the nature of COPD-specific eosinophilia and the underlying type 2 ...