the triggering and amplifying pathways of insulin secretion allow for initiation and fine-tuning of insulin secretory response to glucose and nutrients, as well as other factors, such as paracrine hormones—glucagon-like
We hypothesized that patients after suicide attempt, compared to healthy controls, would have higher insulin and lower glucagon levels in plasma and cerebrospinal fluid and that these changes would be associated to violent behavior.Bendix, MarieUvnas-Moberg, KerstinPetersson, MariaKaldo, ViktorAsberg,...
Specifically, in obesity, impaired responses of sensory neurons to gut delivery of nutrients have been attributed to overeating, body weight gain, and insulin resistance (Boyd et al., 2003; Cheung et al., 2009; Covasa, 2010; Wang et al., 2008). Despite the established importance of sensory...
Understanding the mechanisms that regulate generation and maintenance of pancreatic endocrine cells is critical for developing treatments for diabetes. Pancreatic endocrine hormone-secreting α (glucagon), β (insulin), δ (somatostatin), ε (ghrelin), and PP (pancreatic polypeptide) cells form the isle...
Using α-cell specific gene ablation of G6pc2 in mice, we show that this gene plays a critical role in controlling glucagon secretion independent of alterations in insulin output, islet hormone content, or islet morphology; findings we confirmed in primary human α-cells. Collectively, our data...
The metabolism of the sea raven, Hemitripterus americanus, hepatocyte preparation was studied, emphasizing the roles of insulin and glucagon on carbohydrate status. Sea raven hepatocyte glycogen was depleted throughout the preincubation ... GD Foster,TW Moon - 《Gen Comp Endocrinol》 被引量: 72发...
(n = 5). E) Portion of insulin and glucagon area versus total area in adult control and Stard13ΔPA mouse islets. (n = 10 mice). p < 0.001. Next, we asked whether the F-actin accumulation and disorganization observed in Stard13ΔPA islets affect insulin secretion dynamics. To this ...
Glucagon-Like Peptide-1 Receptor Mediates the Improvement of Glycolipid Metabolism Disorder via AKT and AMPK Signaling Pathways in L02 with Insulin Resistance Background: Glucagon like peptide 1 (GLP-1) has previously been found to regulate glycolipid metabolism in the liver by promoting insulin secret...
e, Serum insulin levels (n = 10 mice per group). f, Blood glucagon levels (n = 12 mice per group). g, Blood corticosterone levels (n = 11 mice per group). h, Blood GLP-1 levels (n = 12 wild-type mice; n = 10 knockout mice). i, Blood growth hormone (GH) levels (n = ...
and molecular function categories (Fig.1d). Hepatic Ago2 deficiency affected the functional clades associated with energy metabolism including fatty acid biosynthesis, AMPK signaling, protein processing, and insulin signaling. Taken together, these results imply the unique role of Ago2 in the expression...