Pretreatment withN-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide (H89), a selective inhibitor of protein kinase A, before glucagon addition markedly attenuated the glucagon effect. This study demonstrates that insulin and glucagon regulate, in an opposing manner, the express...
Insulin and Glucagon regulate pancreatic alpha-cell proliferation Z Liu - 《Plos One》 被引量: 0发表: 2011年 Insulin and Glucagon Regulate Pancreatic α-Cell Proliferation. These studies illustrate that pancreatic α-cell proliferation increases as diabetes develops, resulting in elevated plasma ...
Insulin inhibits HGP through both direct and indirect means, the latter of which include inhibition of glucagon secretion, reduction in plasma nonesterified fatty acid level, decrease in the load of gluconeogenic substrates reaching the liver, and change in neural signaling to the......
摘要: Insulin and glucagon are reciprocal hormones which regulate plasma glucose concentrations. Together, these hormones maintain blood glucose in a narrow range, despite wide variances in glucose production and utilization by the body.关键词: glucose metabolism signal transduction diabetes ...
In healthy humans, insulin and glucagon regulate hepatic glucose production (HGP) to maintain euglycemia during fasting. In contrast, hepatic insulin resistance, along with hyperglucagonemia2, increase fasting HGP in patients with T2D, thereby contributing to hyperglycemia3. Insulin signaling is also ...
Isolated human islets do not always meet the quality standards required for transplant survival and reliable functional in vitro studies. The formation of pseudoislets, i.e. the reaggregation of a defined number of islet cells after dissociation, improve
This invited review focuses on the role of two pancreatic hormones--insulin and glucagon--that trigger signaling pathways in the brain to regulate energy and glucose homeostasis. Unlike in the periphery, insulin and glucagon signaling in the CNS does not seem to have opposing metabolic effects, ...
Inhibition of glucagon gene transcription is accompanied by corresponding decreases in glucagon immunoreactivity in both cell extracts and medium. We conclude that insulin may not only regulate glucagon secretion but also glucagon gene expression. 展开 ...
Despite daily fasting and feeding, plasma glucose levels are normally maintained within a narrow range owing to the hormones insulin and glucagon. Insulin increases glucose uptake into fat and muscle cells through the regulated trafficking of vesicles that contain glucose transporter type 4 (GLUT4). ...
Effect of dietary carbohydrates on insulin and glucagon receptors in a new model of noninsulin-dependent diabetes-SHR/N-corpulent rat. A new congenic strain of rat, the SHR/N-corpulent, provides a good model for noninsulin-dependent diabetes and was used in the present study. Corpulent rat.....