There is increasing evidence that the neurodegenerative processes in Alzheimer's disease (AD) may be related to alterations in calcium homeostasis and that these metabolic changes are not necessarily restricted to the central nervous system. However, previous studies investigating [Ca 2+ ] i in ...
Calcium/Calcineurin/Nuclear Factor of Activated T cells (Ca/CN/NFAT) signalling pathway is the main calcium (Ca2+) dependent signalling pathway involved in the homeostasis of brain tissue. Here, we study the presence of NFATc members in human glioma by using U251 cells and a collection of pr...
Nevertheless, it is unclear whether GABPα regulates IL-7Rα expression in mature T cells, and whether GABPα has additional functions in the control of T-cell homeostasis and effector T-cell responses. In this report, we utilize a mouse model that ablates GABPα from CD4+CD8+ double-...
Therefore, we decided to analyze the role of TSPO in calcium homeostasis and subsequent NOX1-derived ROS production. In accordance with a former study demonstrating elevated cytosolic Ca2+ levels in TSPO-overexpressing cells46, we observed a strong reduction in cytosolic Ca2+ in TSPO-deficient ...
ARL13B sustains immune system homeostasis in the efferent ductules The disruption of luminal homeostasis and sperm compaction suggested that an inflammatory response could be induced in the cKO efferent ducts, as can be seen when motile cilia are disrupted in this epithelium19,20,54. The formation ...
There is increasing evidence that the neurodegenerative processes in Alzheimer's disease (AD) may be related to alterations in calcium homeostasis and that these metabolic changes are not necessarily restricted to the central nervous system. However, previous studies investigating [Ca 2+ ] i in fibro...
While most famous for their role as the powerhouse of the cell, mitochondria have proven to be essential for cardiac homeostasis through the regulation of various biosynthetic and signaling functions beyond OXPHOS, such as calcium buffering, reactive oxygen species (ROS) generation and maintenance, pro...
A conformational shift in mitochondrial complex I during acute hypoxia11 drives acidification of the matrix and the release of free Ca2+ from calcium phosphate (CaP) precipitates. The concomitant activation of the mitochondrial Na+/Ca2+ exchanger promotes the import of Na+ into the matrix. Na+ ...
Neural stem cells (NSCs) are particularly sensitive to changes in both intracellular and extracellular redox states at homeostasis and following injury6,7,8, and the NADPH oxidase complex (Nox/Ncf1) has been implicated as a major source of ROS that impact proliferation and differentiation of NS...
In between, several self-organized, multi-lineage embryo-like structures exist that allow the investigation of the processes underlying the development and homeostasis of different components of the human conceptus.9,11,12,13,14 In the course of human embryogenesis, the oocyte is fertilized by ...