A continuous-flow synthesis of aziridines by palladium-catalyzed C(sp)−H activation is described. The new flow reaction could be combined with an aziridine-ring-opening reaction to give highly functionalized aliphatic amines through a consecutive process. A predictive mechanistic model was developed...
N-alkylation reactions were used as the test case due to their ease of reactant and product detection by electrospray ionization mass spectrometry (ESI-MS) and their great importance in API synthesis. While DESI-MS narrowed the scope of possibilities for reaction selection among some parameters ...
By analyzing the yields of both aldehydes and carboxylic acids as a function of weight hourly space velocity (WHSV), selective synthesis of carboxylic acids was achieved without the formation of corresponding aldehydes. The Pt catalyst exhibited excellent stability, producing 25.2 g of octanoic acid ...
F. Continuous-flow synthesis of functionalized phenols by aerobic oxidation of Grignard reagents. Angew. Chem. Int. Ed. 53, 3353-3357 (2014).He Z, ... Z He,TF Jamison - 《Angewandte Chemie》 被引量: 144发表: 2014年 Continuous‐Flow Synthesis of Functionalized Phenols by Aerobic Oxidation...
catalytic stereoselective 1,4-addition reactions using csf on alumina as solid base a heterogeneous platform for continuous-flow synthesis of gluta 热度: A high-throughput method for detection of DNA in chloroplasts using flow cytometry 热度:
The development of a flow chemistry approach to the anti-fungal fluconazole is described. A continuous, two-reactor, three-step synthesis of fluconazole fr
Living synthesis of conducting polymers including regioregular polymers, polythiophenes, and block copolymers Regioregular poly(3-alkylthiophenes) and other polythiophenes can be prepared by living polymerization which have good solubility, processability and environmental stability. The polymerization method can...
1. Introduction In the last two decades, continuous-flow (CF) synthesis has become a powerful and versatile tool in synthetic organic chemistry. The enhanced mixing properties, heat, and mass transfer of CF systems lead to more precise regulation of the reaction conditions, and thus, better ...
This work presents the synthesis of iron oxide nanocatalysts supported on mesoporous Al-SBA-15 using a continuous flow set-up. The magnetic solid nanoparticles were tested as catalysts for the oxidative disruption of isoeugenol using hydrogen peroxide as the oxidant, showing all high activity (63-...
catalysts Communication Continuous-Flow Synthesis of β-Amino Acid Esters by Lipase-Catalyzed Michael Addition of Aromatic Amines Li-Hua Du 1,*, Rui-Jie Long 1, Miao Xue 1, Ping-Feng Chen 1, Meng-Jie Yang 1 and Xi-Ping Luo 2,* 1 College of Pharmaceutical Science, ZheJiang University of...