CHEMICAL COMMUNICATIONS- ROYAL SOCIETY OF CHEMISTRYFuseS.TanabeN.YoshidaM.H.DoiT.TakahashiS. Fuse, N. Tanabe, M. Yoshida, H. Yoshida, T. Doi, and T. Takahashi, Continuous-flow synthesis of vitamin D3, Chem. Commun., 2010, 46, 8722-8724....
Using continuous flow techniques for multi-step synthesis enables multiple reaction steps to be combined into a single continuous operation. In this mini-r... D Webb,TF Jamison - 《Chemical Science》 被引量: 467发表: 2010年 Suzuki-Miyaura Cross-Coupling Reactions in Flow: Multistep Synthesis En...
The process tolerates a broad range of functional groups, including oxidation-sensitive functionalities such as alkenes, amines, and thioethers. By integrating a benzyne-mediated in-line generation of arylmagnesium intermediates with the aerobic oxidation, a facile three-step, one-flow process, ...
Continuous Flow Synthesis of Chiral Amines in OrganicSolvents: Immobilization of E. coli Cells ContainingBoth ωTransaminase ... Jamison, Continuous flow synthesis of chiral amines in organic solvents: immobilization of E. coli cells containing both ω-transaminase and PLP, Org. Lett... LH Andrade...
The continuous flow synthesis of functional thiophene derivatives was examined. Methodology for the lithiation of thiophene building blocks was developed using a commercial bench-top flow reactor. In addition, the advantages of flow processing were demonstrated in the synthesis of a high performance organ...
A continuous-flow reactor (Corning G1 reactor) was hereby introduced for Fischer indole synthesis of 3-methylindole by reaction of phenyl hydrazines and propylaldehyde. Stoichiometric Lewis acid, ZnCl 2 , was supplied as catalyst as well as remover of NH 3 which generated during the indole ring...
The WO3 crystals produced were all within the nanorange with aspect ratios of ca. 2.88, 2.61 and 4.24 depending on the conditions used. The effects of the heated water stream to precursor solution flow ratios as well as reaction temperature were studied. Our synthesis method has the advantage ...
Continuous-flow chemistry is an enabling technology which offers great advantages when combined with green chemistry principles toward the development of a more sustainable chemical process. Herein, we present some of the developments made so far on the continuous-flow process that can help researchers...
The development of a flow chemistry approach to the anti-fungal fluconazole is described. A continuous, two-reactor, three-step synthesis of fluconazole from 2-chloro-2′,4′-difluoroacetophenone was achieved with no intermediate purification. The synthesis has been successfully demonstrated on a ...
5-Hydroxymethylfurfural (HMF) was synthesized from glucose in a slug flow capillary microreactor, using a combination of AlCl3 and HCl as the homogeneous catalyst in the aqueous phase and methyl isobutyl ketone as the organic phase for in-situ HMF extraction. After optimization, an HMF yield of...