Following synthesis of 1,25(OH)2D3, it secretes into the circulation from the renal tubular cells, and activates specific intra-nuclear, vitamin D receptors (VDR) in target cells (Fig. 1). Sign in to download hi-res image Fig. 1. A simplified diagram of the different stages of vitamin...
PRISMA Diagram of Study Selection View LargeDownload Gray literature indicates material not published in recognized scientific journals; BP, blood pressure; DBP, diagnostic BP; RCT, randomized clinical trial; and SBP, systolic BP. Figure 2. Results of Trial-Level Meta-analysis for Systolic Blood ...
Analytic Framework: Screening for Vitamin D Deficiency in Adults View LargeDownload Figure 2. Literature Search Flow Diagram: Screening for Vitamin D Deficiency in Adults View LargeDownload KQ indicates key question. Figure 3. Effect of Vitamin D Treatment on Mortality Stratified by Setting View ...
Diagram of the metabolic processes providing vitamin D and its metabolites to various tissues in the body. Tissue distribution of vitamin D and 25(OH)D based on simple diffusion (red arrows) or endocytosis (green arrows). Endocytosis requires the tissue-specific meglin-cubilin system, whereas ...
Flow diagram of study participants. Full size image Table1describes the gender and geography wise mean anthropometric parameters and vitamin D concentrations of subjects enrolled in the study. The mean (± SD) age and gender standardized Z-scores for height, weight and BMI of the study populati...
Vitamin D signaling plays critical roles in tissues such as muscle, aiding in function, maintenance, and development [7,8]. Figure 1. Vitamin D synthesis pathway. Created with BioRender.com. 1.1. Whole-Body VDR Knockout Mice Several in vivo studies have shown that the deletion of VDR in ...
Figure 1. PRISMA Flow Diagram. Table 1 presents the characteristics of the eight included studies that investigated the effects of vitamin D supplementation on respiratory infections in children under six years old [31,32,33,34,35,36,37,38]. These studies were conducted between 2012 and 2021...
(antirachitic/antiosteoporotic) effects, as well as newly recognized bone anabolic and counter-ectopic calcification functions, as the fraction of the iceberg above the water line. Thebulkof VDR’s actions are novel extraosseous effects that are diagramed in the submerged portion of the iceberg. ...
Chronic and harmful substance use is associated with a cluster of harms to health, including micronutrient deficiencies. Maintaining adequate levels of vitamin D is important for musculoskeletal and other aspects of health. In this prospective longitudin
vitamin D is known to be sunlight []. Coherent with the literature data, it is expected that we will detect less Vit-D deficiency in the sunny period. Health workers can be explaining the important effect of the sun on vitamin D synthesis and advise patients to benefit from more sunlight....