Hint:Chromosomes are made up of chromatin. Chromatin made up of the threads of DNA forms the structure of chromosomes. The DNA gets condensed to form chromosomes. Genes are the segments of DNA. The code for proteins. This means chromosomes are made up of DNA which contains ...
Recent studies have revealed new functions of peri- centrin in the maintenance of cell cycle integrity and regulation of DNA damage checkpoint. It was indicated that mutations in the gene PCNT result in Majewski osteodysplastic primordial dwarfism type II (MOPD II) and Seckel syndrome, two ...
Repressive chromatin structures need to be unravelled to allow DNA-binding proteins access to their target sequences. This de-repression constitutes an important point at which transcription and presumably other nuclear processes can be regulated,. Energy-consuming enzyme complexes that facilitate the ...
2. Composition of the Nucleolus: The nucleolus contains various components, including proteins, ribonucleic acid (RNA), and some deoxyribonucleic acid (DNA). However, its primary constituents are proteins and RNA. 3. Function of the Nucleolus: The main function of the nucleolus is to synthesize ...
The SWI/SNF components provide the holoenzyme with the capacity to disrupt nucleosomal DNA and thus facilitate stable binding of various components of the transcription initiation complex at promoters. 展开 关键词: Chromatin Nucleosomes Yeasts RNA Polymerase II DNA-Binding Proteins TATA-Box Binding ...
We have performed a preliminary characterization of the chromatin proteins recruited to DNA beads, and identified the Xenopus polo-like kinase Plx1 as a ... PP Budde,A Kumagai,WG Dunphy,... - 《Journal of Cell Biology》 被引量: 193发表: 2001年 Plx1 is required for chromosomal DNA replica...
Structure and function of DnaA N-terminal domains: specific sites and mechanisms in inter-DnaA interaction and in DnaB helicase loading on oriC. DnaA forms a homomultimeric complex with the origin of chromosomal replication (oriC) to unwind duplex DNA. The interaction of the DnaA N terminus ...
Once we have matrices containing read densities, or DNA sequences, from regions of interest, we may be interested in partitioning them in order to isolate leading trends either in terms of chromatin features (for read densities) or in terms of motif contents (for DNA sequences). Each partitio...
IL-2 gene expression in activated T-cells is initiated by chromatin remodeling at the IL-2 proximal promoter and conversion of a transcriptional repressor ... L Shi,D Qiu,G Zhao,... - 《Nucleic Acids Research》 被引量: 97发表: 2007年 CsA-sensitive purine-box transcriptional regulator in ...
Furthermore, it is important to remember that these rough estimates of affinity are based solely on cell-free binding studies using small pieces of naked DNA. In vivo, the tertiary structure of DNA, neighboring regions of chromatin/DNA, additional transcription factors, other proteins, etc. may ...