Taurine conjugation of bile acids protects human cells in culture - Gaull, Wright - 1987Gaull, G. E., and C. E. Wright. 1987. Taurine conjugation of bile acids protects human cells in culture. Adv. Exp. Med. Biol. 217: 61-67....
5. The formation of glycyl or tauryl derivatives of the bile acids. [L.con-jugo, pp. -jugatus, to join together] Medical Dictionary for the Health Professions and Nursing © Farlex 2012 conjugation 1. Chemical combination or linkage of chemical groups to organic molecules, often to produc...
ABSTRACT: We studied the postnatal development of hepatic bile acid conjugation in the rat. Overall conjugating activity (homogenate assay) and the activity of the individual enzymes involved in the two step conjugation reaction (coenzyme A-bile acid thioester formation by microsomal cholyl-CoA ligase...
Bile salts and acids have been implicated in the etiology of colon cancer, possibly through their ability to cause DNA damage. Taurineconjugated and nonconjugated forms of three bile salts and one bile acid were tested for DNA repairinducing potential and for cellular toxicity in a recently develo...
The farnesoid X receptor (FXR; NR1H4) regulates bile acid and lipid homeostasis by acting as an intracellular bile acid-sensing transcription factor. Several identified FXR target genes serve critical roles in the synthesis and transport of bile acids as well as in lipid metabolism. Here we ...
Conjugation, particularly of mono- and dihydroxy bile acids, may also decrease the potential toxicity of these compounds to the intestinal brush border and to the hepatocyte (7, 27). At birth the enterohepatic circulation of bile acids is not fully developed. Bile acid synthesis is decreased (...
Dietary pectin compared to cellulose greatly increased the G/T accompanying the decrease in the concentration of hepatic taurine. However, the N -acyltransferase reaction produced taurine- but little glycine-conjugated bile acids when both taurine and glycine were coexisted at the concentrations of ...
The aim of this study was to define whether N-acetylglucosaminidation is a selective conjugation pathway of structurally related bile acids in humans. The ... HU Marschall,H, Matern,H, Wietholtz,... - 《Journal of Clinical Investigation》 被引量: 346发表: 1992年 Glutathione transferases in...
(Jan. 1986) “Antisera of Designed Specificity for Subunits of Guanine Nucleotide-Binding Regulatory Proteins,” Proc. Natl. Acad. Sci. 83:265-269. Otteson, Kenneth M. (1983) “Comparisons of Peptide Sequences with Deprotection Problems in Fmoc Solid Phase Peptide Synthesis,” Proceedings of ...
In order to establish the position of conjugation of bile acids with glucose or N-acetylglucosamine, glucosides of chenodeoxycholic and hyodeoxycholic acids and of 13C-labeled cholic, lithocholic, chenodeoxycholic, hyodeoxycholic, and ursodeoxycholic acids, and N-acetylglucosaminides of ursodeoxycholic, iso...