The Bronsted-Lowry acid-base theory includes the concepts of conjugate acids and conjugate bases. When an acid dissociates into its ions in water, it loses a hydrogen ion. The species that is formed is the acid's conjugate base. A more general definition is that a conjugate base is the b...
noun Chemistry A chemical compound that has been formed by the joining of two or more compounds. from The Century Dictionary. To join together; specifically, to join in marriage; unite by marriage. In grammar, to inflect (a verb) through all its various forms, as voices, moods, tenses, ...
(In Arrhenius theory, ammonia had to be fictionalized as NH4OH so that it could be regarded as a source of hydroxide ions in the solution.) As another example, HF+H2O⇌F−+H3O+ Here water is the base and HF is the acid. (Bronsted-Lowry theory allows a substance to be either ...
Chemistry. of or noting two or more liquids in equilibrium with one another. (of an acid and a base) related by the loss or gain of a proton: NH3 is a base conjugate to NH4+. NH4+ is an acid conjugate to NH3. Alsocon ju·gat ed.(of an organic compound) containing two or more...
The Medicilon peptide synthesis research team has now established a complete system from upstream synthesis of unnatural amino acid structural units, peptide drug modification and large-scale synthesis, to downstream peptide drug signal transduction pathways and mechanism of action research. Through multi-...
By using O-SP-core (O-SPcNH 2 ) polysaccharide, isolated from Vibrio cholera O1 lipopolysaccharide (LPS) and related synthetic substances, a detailed study of factors that affect conjugation of bacterial polysaccharides to protein carriers through squaric acid chemistry to form conjugate vaccines has...
flexneri 2a (SCV-Sf2a) and 3a (SCV-Sf3a) using squaric acid chemistry to result in single point sun-burst type display of OSP from carrier protein rTTHc, a 52 kDa recombinant protein fragment of the heavy chain of tetanus toxoid. We confirmed structure and demonstrated that these conjugates...
Conjugation of BDMC was carried out using the acid form of the St-PGA-CL and proceeded as follows. Briefly, in a two-necked round bottom flask, fitted with a stirrer bar and two septae, the star polymer was dissolved in 10 mL of anhydrous dimethylformamide (DMF) under nitrogen atmospher...
4.2.2. Nature of Amino Acid Side Chains Positively Charged Side Chains The nature of the cationic amino acid side chain also plays a role in the penetration abilities of a membrane active peptide (Figure 3C). With regards to naturally occurring positively charged amino acids, arginine and lysine...
in high quantities in tumors, ensuring that VIP126 is released near the cancer cells and less around normal cells. VIP126, when delivered as a component of VIP236, kills tumor cells in mouse cancer models without the toxicity seen with standard chemotherapy. VIP236 may be a new modality for...