Interactive 3D animation of SN2' (prime) substitution at an allylic centre for students studying University chemistry
1. The only difference between the two molecules is the carboxymethyl moiety on the PDG acid which is hypothesized to anchor the conjugate to the protein. Both conjugates were subject to isothermal titration calorimetry analysis at 30 °C, from which the binding parameters could be extracted. The...
CD33 is a sialic acid binding receptor and a myeloid differentiation antigen overexpressed in 90% of leukemic blasts [9]. In a sample of 621 patients, CD33 expression was highest in AML patients withNPM1mutations and lower in complex karyotypes and t(8;21) translocations [10]. The fact tha...
Lytic peptide Hecate (23-amino acid (AA)) fused with a 15-AA fragment of human chorionic gonadotropin-beta (CG-beta), Hecate-CGbeta conjugate (H-CGbeta-c) selectively binds to and destroys tumor cells expressing LH/chorionic gonadotropin receptor (Lhcgr). Transgenic mice (6.5 month old) exp...
Thus, the effect on nanojar substitution and breakdown pattern of a number of variables, such as concentration of reagent (acid or conjugate base), acidity of reagent (pK(a)), effect of acid vs conjugate base, steric effects, aromaticity, incarcerated anion and size of the nanojar, is ...
6-trideoxyglucopyranose) attached to the asparagine residue in the acceptor sequon D/E-X1-N-X2- S/T with X1and X2as any amino acid except proline. The successful expression of PglB was instrumental linking bacterial polysaccharides to selected carrier proteins inE. coli.This led to the ...
The DUB E32* mutant is a single-nucleotide mutant replacing the amino acid at position 32 of the DUB protein with a stop codon. Data shown is the average of three biological replicates. Error bars show average with s.d. Source Data Supplementary information Supplementary Fig. 1 Uncropped gel...
A tumour microenvironment imposes barriers to the passive diffusion of molecules, which renders tumour penetration an unresolved obstacle to an effective anticancer drug delivery. Here, we present a γ-glutamyl transpeptidase-responsive camptothecin–pol
Bile acid conjugates are forms of bile acids that are linked with glycine, taurine, sulfate, or glucuronides, often found in association with proteins and other molecules, and are typically present in plasma and urine. AI generated definition based on: Encyclopedia of Separation Science, 2000 ...
[210] Doxurubicin HCl Alginate microbeads templated with internal drug conjugate voids Sustained release of ≤15% in initial 24 h, vs 99% over 24 h for non-encapsulated drug [148] Dual-functionalised core/shell nanoparticles of chitosan-graft-polyacrylic acid-conjugated drug, coated in dual-func...