Concepts in Clinical Pharmacokinetics, Fifth ed. American Society of Health-System Pharmacists, Bethesda.Dipiro, JT, Spruill, WJ, Wade, WE, Blouin, RA and Pruemer, JM (2010). Concepts in Clinical Pharmacokinetics. 5th edn. American Society of Health-System Pharmacists: Bethesda, MD....
Pharmacokinetics (PK) is defined loosely as what the body does to the drug and is comprised of the absorption, distribution, metabolism, and elimination (ADME) profile. A key principal in clinical pharmacology is studying how drug PK differs amongst populations. Initial PK studies in humans for ...
- 《Clinical Pharmacology & Therapeutics》 被引量: 213发表: 1998年 Concepts in Clinical Pharmacokinetics The past four editions of "Concepts in Clinical Pharmacokinetics" have helped simplify a complex subject for thousands of pharmacy students and practitione... JT Dipiro - American Society of ...
P Reetze-Bonorden,J B?Hler,E Keller - 《Clinical Pharmacokinetics》 被引量: 228发表: 1993年 Prescribing an equilibrated intermittent hemodialysis dose in intensive care unit acute renal failure. Prospective, formal, blood-side, urea kinetic modeling (UKM) has yet to be applied in intermittent ...
Drugs that undergo extensive first-pass elimination exhibit pronounced interindividual variation in plasma concentrations or drug concentration-time curves after oral administration. This variation, often reflected in variability in drug response, poses one of the major problems in the clinical use of these...
Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a d...
Pharmacological agents should be used as an aid to a structured diet and exercise regimen in the treatment of obesity. Weight loss agents may result in initial weight loss, but sustained weight loss is not always achieved even with continuation of treatment. The effect of weight loss obtained wh...
A major goal in clinical pharmacology is the quantitative prediction of drug effects. The field of pharmacokinetic–pharmacodynamic (PK/PD) modelling has m... C Csajka,D Verotta - 《Journal of Pharmacokinetics & Pharmacodynamics》 被引量: 260发表: 2006年 A regulatory perspective on pharmacokinetic...
Pathophysiological changes are common in critically ill patients, and can alter the time course of drug concentrations following dosing. The latter is termed pharmacokinetics (PK), and describes the relationship between dose administered and drug concentrations in plasma. Thus, modifications in PK necessi...
Clinical PharmacokineticsDahyot C, Marchand S, Bodin M, Debeane B, Mimoz O, Couet W. Application of basic pharmacokinetic concepts to analysis of microdialysis data: illustration with imipenem muscle distribution. Clin Pharmacokinet. 2008;47(3):181–9. View Article...