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in the field ofpharmacokinetics, the definitions and formulas for the parameters must be agreed upon, and the methods used to calculate them understood. This understanding includes assumptions and domains of validity, for the utility of the parameter values depends upon them. This chapter exa...
Key physicochemical properties including molecular weight, degree of ionization, protein binding, and lipid solubility will greatly influence antibiotic distribution. Lipophilic agents (such as fluoroquinolones) typically have a largeVdwith greater tissue and intracellular penetration. Alternatively, hydrophilic a...
Fisher, R.S.; Van Emde Boas, W.; Blume, W.; Elger, C.; Genton, P.; Lee, P.; Engel, J. Epileptic seizures and epilepsy: Definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE).Epilepsia2005,46, 470–472. [Google Schol...
With the aim of clarifying this aspect and facilitating the understanding and interpretation of the results obtained in the articles collected in this review,Table 2shows all the statistical metrics used in the articles analyzed, as well as their possible abbreviations, formulas, definitions, and inte...