Table 1. Cytotoxic activities of incomptines A (IA) and B (IB) isolated from dichloromethane extract of the aerial parts of Decachaeta incompta. Although the data are limited, a structure-cytotoxicity relationship was established from the CC50 values in the tested leukemia cells and revealed...
The analysis (Figure 5) of the superimposed poses of incomptine A (IA), parthenolide (Pa), and methotrexate (MTX) versus six pharmacological targets showed a close interaction with the site receptor in all cases, varying in ΔG, affinity, and several amino acids (Table 2). This observation...